{"id":"W3021258670","doi":"10.1016/j.jagp.2020.04.026","title":"Neurobiologic Rationale for Treatment of Apathy in Alzheimer's Disease With Methylphenidate","year":2020,"lang":"en","type":"review","venue":"American Journal of Geriatric Psychiatry","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"National Center for Advancing Translational Sciences; National Institute on Aging; U.S. Department of Veterans Affairs","keywords":"Apathy; Methylphenidate; Psychology; Neuroscience; Prefrontal cortex; Dopamine; Cognition; Ventromedial prefrontal cortex; Disease; Psychiatry; Attention deficit hyperactivity disorder; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005249135,0.00102959,0.001061241,0.002006211,0.0003669322,0.000734358,0.001390081,0.001643057,0.002948529],"category_scores_gemma":[0.0007535642,0.0002889572,0.0005967515,0.001365861,0.000749769,0.001046727,0.0004879808,0.003224197,0.00210125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008203315,"about_ca_system_score_gemma":0.0008883698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001744914,"about_ca_topic_score_gemma":0.003191371,"domain_scores_codex":[0.9998461,0.00003188211,0.00003150557,0.00003383927,0.00004500796,0.00001164367],"domain_scores_gemma":[0.9998389,0.00007570355,0.00002272254,0.000006601951,0.00004260413,0.00001346043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001859516,0.0001573414,0.0002049461,0.01330494,0.0001312237,0.0004199303,0.00006654659,0.0003952805,0.002005416,0.009147735,0.04380616,0.9301745],"study_design_scores_gemma":[0.0001112741,0.0001575762,0.001460536,0.004152229,0.0001638763,0.002370441,0.00004091754,0.0001580068,0.0008730778,0.003314957,0.9871711,0.00002593892],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001683305,0.9970764,0.0001362834,0.0004881745,0.0003679693,0.00001311084,0.00004361981,0.000010418,0.001695667],"genre_scores_gemma":[0.001370244,0.9962834,0.0003665783,0.0005491216,0.0002489766,0.00002559079,0.00005438178,0.000002196082,0.0010996],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002948529,"threshold_uncertainty_score":0.009863794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035533113382163,"score_gpt":0.3553056083925585,"score_spread":0.2517522970543422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}