{"id":"W3021311268","doi":"10.1039/d0ra03235b","title":"One-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups","year":2020,"lang":"en","type":"article","venue":"RSC Advances","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Université de Paris; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Thiazolidine; Oxime; Bearing (navigation); Chemistry; Ligation; Combinatorial chemistry; Medicinal chemistry; Stereochemistry; Internal medicine; Medicine; Computer science; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003259586,0.00009433833,0.0001411971,0.000008061746,0.00005167312,0.00003450204,0.00008416311,0.00005924857,0.00002026195],"category_scores_gemma":[0.00009321304,0.00008962605,0.00005658439,0.00005478352,0.0000422552,0.00001272362,0.00007936861,0.00004928982,0.000008727057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004292766,"about_ca_system_score_gemma":0.000005050744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002246913,"about_ca_topic_score_gemma":0.00001428719,"domain_scores_codex":[0.9993647,0.0000130471,0.0001268751,0.0002969956,0.00008501559,0.0001133082],"domain_scores_gemma":[0.9997226,0.00002066461,0.00005567158,0.0001041413,0.00001975163,0.00007717649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002067932,0.00001407962,0.003347698,0.00001198719,0.00003851449,4.078659e-7,0.00003610845,0.00001590822,0.9848431,0.00003835052,0.00005533157,0.01157782],"study_design_scores_gemma":[0.00016627,0.0000512607,0.002814379,0.00001614283,0.00003769885,3.778125e-7,0.00009740131,0.0002028605,0.9830804,0.0004639618,0.01292386,0.000145417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927587,0.004375628,0.00158888,0.0007311556,0.00001439533,0.00003804453,0.00001412985,0.00001461554,0.000464481],"genre_scores_gemma":[0.9958474,0.001520044,0.001717271,0.0003421131,0.0003977982,0.000004857754,0.00008265214,0.000009926048,0.00007793649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01286853,"threshold_uncertainty_score":0.3654844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330018224441458,"score_gpt":0.2293199884619948,"score_spread":0.2160198062175802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}