{"id":"W3021366882","doi":"10.1158/1535-7163.mct-20-0087","title":"Combined Targeting of the BRD4–NUT–p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Optometric Education Trust Fund; Paraza Pharma (Canada)","funders":"National Cancer Institute; National Institute of General Medical Sciences; Genentech","keywords":"Bromodomain; Nut; BRD4; Biology; Cancer research; Medicine; Pharmacology; Chemistry; Genetics; Histone; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387994,0.0003063216,0.0004569752,0.0002776273,0.0001203622,0.000244755,0.0003312464,0.0002420258,0.0007974405],"category_scores_gemma":[0.00007189961,0.0001374778,0.0002578215,0.0001878925,0.0001934122,0.0001774696,0.0002125227,0.0006879974,0.0002405541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003823373,"about_ca_system_score_gemma":0.0003364444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008858379,"about_ca_topic_score_gemma":0.002793702,"domain_scores_codex":[0.9998989,0.00001334637,0.000007359987,0.00001648918,0.00003353358,0.00003034974],"domain_scores_gemma":[0.9999653,0.000005187436,0.000005409065,0.000004151928,0.000003106301,0.00001687514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001165809,0.000480665,0.0004791215,0.00009474739,0.00003849918,0.000117254,0.0000170059,0.000493418,0.9860858,0.0001865273,0.000357079,0.01048403],"study_design_scores_gemma":[0.0004291549,0.00411269,0.005311585,0.000005781233,0.00007838613,0.0005906693,0.00002999223,0.003370121,0.9817237,0.00006869298,0.00426897,0.00001021176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942263,0.001680361,0.001538389,0.0001375876,0.00004328504,0.00009259573,0.0003337338,0.00009893842,0.001848766],"genre_scores_gemma":[0.9970029,0.0005564171,0.001097083,0.0000331004,0.0000068792,0.00004020878,0.0003013643,0.000008010831,0.0009539882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008858379,"threshold_uncertainty_score":0.00277406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169896436044079,"score_gpt":0.2392130122808768,"score_spread":0.227514047920436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}