{"id":"W3021368626","doi":"10.1186/s12866-020-01796-6","title":"Low phosphatase activity of LiaS and strong LiaR-DNA affinity explain the unusual LiaS to LiaR in vivo stoichiometry","year":2020,"lang":"en","type":"article","venue":"BMC Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; Ministero dello Sviluppo Economico; Deutsche Forschungsgemeinschaft; York University","keywords":"Phosphorylation; Biology; Phosphatase; In vivo; Biophysics; Cell biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002404369,0.0002357737,0.0003387285,0.0000813084,0.00005708477,0.00001452966,0.000389806,0.000462401,0.00003721669],"category_scores_gemma":[0.0002321426,0.0001896444,0.00007570747,0.0002887392,0.0002768339,0.000003559644,0.0005940172,0.0002132308,0.00000925718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001249954,"about_ca_system_score_gemma":0.00009966696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005591898,"about_ca_topic_score_gemma":0.0005785614,"domain_scores_codex":[0.9985549,0.0001914888,0.0002912099,0.0005515646,0.00003795029,0.000372851],"domain_scores_gemma":[0.9992778,0.00005259433,0.0001318198,0.0003843028,0.00004316471,0.0001103186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004618409,0.0001024174,0.002011986,0.00003813733,0.00003120979,0.000002602145,0.00008896684,0.00001643385,0.9946567,0.0000919896,0.001074943,0.001422741],"study_design_scores_gemma":[0.0006788376,0.0008867948,0.00300379,0.00001202016,0.00001367458,0.0000161681,0.0001097806,0.00001653273,0.9763843,0.0000090807,0.01865878,0.0002102512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969922,0.0006242029,0.0003528324,0.0009784838,0.0001859384,0.0003493802,0.0004655364,0.00001281312,0.00003862428],"genre_scores_gemma":[0.9981707,0.0001813873,0.0006864335,0.0006592564,0.000152513,0.00001632565,0.00007096381,0.00002010362,0.00004231427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01827244,"threshold_uncertainty_score":0.7733474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526984025883614,"score_gpt":0.2353798847804014,"score_spread":0.2201100445215653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}