{"id":"W3021378100","doi":"10.1158/0008-5472.can-19-2270","title":"HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Institutes of Health Research; Austrian Science Fund; European Commission","keywords":"Ubiquitin ligase; Carcinogenesis; GTPase; Cell biology; Ubiquitin; Mutation; Biology; DNA ligase; Cancer research; Homeostasis; Chemistry; Genetics; Cancer; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003613784,0.0001351298,0.0003163813,0.0001938577,0.00008375578,0.00001227498,0.0001265733,0.0001272355,0.0004213403],"category_scores_gemma":[0.0002228011,0.0001334363,0.0001259803,0.0009185631,0.0001717316,0.00006639637,0.0001413396,0.0004649659,0.00005185214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003955728,"about_ca_system_score_gemma":0.0007298656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008056886,"about_ca_topic_score_gemma":0.0000286619,"domain_scores_codex":[0.9976873,0.0001724805,0.000298735,0.0004112353,0.001000617,0.0004296469],"domain_scores_gemma":[0.9987285,0.00006324253,0.00006716204,0.0003469531,0.0004615677,0.0003326342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006123381,0.00008025346,0.0034302,0.0006375338,0.00009811598,0.000107143,0.0004758702,0.00007977026,0.9761029,0.0000271705,0.01206376,0.0062849],"study_design_scores_gemma":[0.002122189,0.0005042581,0.008778436,0.0005562992,0.00009510432,0.000009764192,0.0001530621,0.0006666728,0.9816076,0.00004471798,0.00531693,0.0001450113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844264,0.01010319,0.0006678078,0.0023557,0.0001149208,0.0009315447,0.0000646145,0.00005096794,0.001284871],"genre_scores_gemma":[0.997667,0.0009442012,0.0001155543,0.0004473008,0.0003085108,0.000188736,0.00003777748,0.0000522633,0.0002386199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01324066,"threshold_uncertainty_score":0.5441373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09764941686605956,"score_gpt":0.3882792780975191,"score_spread":0.2906298612314596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}