{"id":"W3021400239","doi":"10.1038/s41467-020-16066-2","title":"Context specificity of the EMT transcriptional response","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"Context (archaeology); Epithelial–mesenchymal transition; Biology; Computational biology; Transition (genetics); Gene; Cancer research; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203768,0.0002000907,0.0004284655,0.0002049186,0.0002600478,0.0005419318,0.0001313321,0.0002167558,0.00160461],"category_scores_gemma":[0.0003646747,0.000167225,0.0003564886,0.0001503063,0.0002752607,0.000255576,0.000344118,0.0006026809,0.0004962793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002906038,"about_ca_system_score_gemma":0.0002698682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005800872,"about_ca_topic_score_gemma":0.001670948,"domain_scores_codex":[0.9996543,0.00004128634,0.00001952424,0.0001242546,0.0001010234,0.0000595435],"domain_scores_gemma":[0.9998061,0.00005400301,0.00003712861,0.00002822714,0.00004545172,0.00002909568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004889959,0.000005423302,0.0004160382,0.00002326842,0.000002855765,0.0000132442,0.000008162393,0.0001182376,0.998576,0.00004553933,0.00002849963,0.000713745],"study_design_scores_gemma":[0.000004172309,0.0001040748,0.04278063,0.000009149893,0.00001427281,0.000165745,0.00006997422,0.001908343,0.9522488,0.0001411844,0.002540299,0.00001333452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847763,0.001784413,0.007185316,0.0001598669,0.00005146036,0.00004327227,0.002234982,0.0001859869,0.00357845],"genre_scores_gemma":[0.9940206,0.000517529,0.002507296,0.0001418669,0.00001086157,0.00003690296,0.001343637,0.00004975345,0.001371482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00160461,"threshold_uncertainty_score":0.005367994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03423784688645678,"score_gpt":0.2665214785738771,"score_spread":0.2322836316874203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}