{"id":"W3021433360","doi":"10.1002/hbm.25023","title":"<scp>Grab‐AD</scp>: Generalizability and reproducibility of altered brain activity and diagnostic classification in Alzheimer's Disease","year":2020,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Chinese Academy of Sciences; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Default mode network; Neuroimaging; Resting state fMRI; Parahippocampal gyrus; Neuroscience; Psychology; Connectome; Alzheimer's disease; Biomarker; Alzheimer's Disease Neuroimaging Initiative; Receiver operating characteristic; Brain activity and meditation; Medicine; Cognition; Disease; Temporal lobe; Functional connectivity; Cognitive impairment; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02766923,0.0005132094,0.001128394,0.001484977,0.0004411425,0.001359756,0.001030926,0.000686244,0.001746873],"category_scores_gemma":[0.06614747,0.000299849,0.002085644,0.002107618,0.000945488,0.0005087635,0.0009882776,0.0005144341,0.000418656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003782807,"about_ca_system_score_gemma":0.0005393216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004982889,"about_ca_topic_score_gemma":0.007595375,"domain_scores_codex":[0.9889486,0.006899865,0.0009919464,0.001769458,0.001293793,0.00009643356],"domain_scores_gemma":[0.9256874,0.0497152,0.01021785,0.009680196,0.004189613,0.0005098208],"domain_codex":null,"domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007295535,0.0001781102,0.8090173,0.003066334,0.1012999,0.0003278917,0.0004444452,0.004586101,0.002987606,0.0007189618,0.01212466,0.05795332],"study_design_scores_gemma":[0.0007735243,0.0006472062,0.9682496,0.000317032,0.0145911,0.0006482599,0.0000980045,0.006588803,0.001125204,0.001849974,0.005061938,0.00004937972],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9355932,0.01897764,0.01650385,0.002014405,0.0003468718,0.0007284985,0.0195359,0.0005988526,0.00570085],"genre_scores_gemma":[0.9890636,0.0007946457,0.002361455,0.000464032,0.0001197198,0.0002403787,0.006483375,0.000124607,0.0003482944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9723307,"threshold_uncertainty_score":0.1463307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1352805630562571,"score_gpt":0.306299874421525,"score_spread":0.1710193113652679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}