{"id":"W3021442601","doi":"10.1001/jamaoncol.2020.0910","title":"Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer","year":2020,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":398,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Canadian Red Cross Society; Dalhousie University; Moncton Hospital; Juravinski Cancer Centre; Ottawa Hospital; Saskatchewan Cancer Agency; St. John’s Health Sciences Centre; Université de Sherbrooke; Queen's University; Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal; Université Laval","funders":"Ipsen; Eisai; Celgene; Amgen","keywords":"Medicine; Microsatellite instability; Internal medicine; Colorectal cancer; Oncology; Cetuximab; Regorafenib; Tremelimumab; Irinotecan; Cancer; Ipilimumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001301456,0.0008660796,0.002062357,0.0004728071,0.0003263931,0.0007479706,0.0006638802,0.0008232308,0.002812716],"category_scores_gemma":[0.002292817,0.0003542732,0.001366181,0.0003773182,0.0005956608,0.0007841524,0.0004136961,0.001783805,0.000291853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001169339,"about_ca_system_score_gemma":0.001543947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001587196,"about_ca_topic_score_gemma":0.007538321,"domain_scores_codex":[0.9993616,0.0003216605,0.00005075226,0.0001036521,0.00005762613,0.0001046653],"domain_scores_gemma":[0.9986075,0.0004327932,0.0002180539,0.00006584943,0.00005490127,0.0006209423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9168504,0.009102195,0.003716802,0.0005821164,0.001481494,0.0000577775,0.00005094103,0.001211957,0.002763669,0.00006854988,0.0007708606,0.06334328],"study_design_scores_gemma":[0.4015201,0.5678583,0.0226361,0.0001158793,0.002416457,0.000138556,0.00006192596,0.002025797,0.001475208,0.0001876406,0.001525978,0.00003802768],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923657,0.005036333,0.0001462162,0.0004270686,0.0002651853,0.0004427786,0.0001644936,0.00003210488,0.001120142],"genre_scores_gemma":[0.9972166,0.001085331,0.0004050008,0.0003280194,0.0002095224,0.0002563359,0.0001491601,0.000004107761,0.0003457587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002812716,"threshold_uncertainty_score":0.009409487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005834023752853325,"score_gpt":0.273599230731202,"score_spread":0.2677652069783487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}