{"id":"W3021442601","doi":"10.1001/jamaoncol.2020.0910","title":"Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer","year":2020,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":398,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Canadian Red Cross Society; Dalhousie University; Moncton Hospital; Juravinski Cancer Centre; Ottawa Hospital; Saskatchewan Cancer Agency; St. John’s Health Sciences Centre; Université de Sherbrooke; Queen's University; Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal; Université Laval","funders":"Ipsen; Eisai; Celgene; Amgen","keywords":"Medicine; Microsatellite instability; Internal medicine; Colorectal cancer; Oncology; Cetuximab; Regorafenib; Tremelimumab; Irinotecan; Cancer; Ipilimumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001359715,0.0001612409,0.000633709,0.00007342676,0.0000240979,0.000003297076,0.00004861736,0.000163041,0.0001749667],"category_scores_gemma":[0.00007670848,0.0001227227,0.00009263284,0.0003072475,0.000152711,0.00007432292,0.00003200481,0.000235032,0.000005453295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005025812,"about_ca_system_score_gemma":0.0002551678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000345431,"about_ca_topic_score_gemma":0.0002855156,"domain_scores_codex":[0.9988371,0.0001333804,0.0004006028,0.0002423867,0.0001738711,0.0002126759],"domain_scores_gemma":[0.9993144,0.00009583288,0.0002473586,0.00009943737,0.0001660501,0.00007689828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3485377,0.0006622286,0.3722331,0.0006602395,0.000245529,0.0001066233,0.004758575,0.00001698993,0.1504605,0.00000236453,0.0001746756,0.1221415],"study_design_scores_gemma":[0.05409076,0.06899311,0.5277138,0.0003072621,0.0001116313,0.000004110177,0.0004695312,0.00001724762,0.3473959,7.850723e-7,0.0007630623,0.0001328868],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954535,0.0004839702,0.000002688076,0.002117718,0.000140727,0.001206818,0.00005359966,0.00002195056,0.0005190678],"genre_scores_gemma":[0.9988055,0.00008197123,0.00006415942,0.0005893335,0.00004669161,0.0001590712,0.0002200053,0.00002124046,0.00001201308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2944469,"threshold_uncertainty_score":0.5004488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005834023752853325,"score_gpt":0.273599230731202,"score_spread":0.2677652069783487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}