{"id":"W3021472336","doi":"10.1038/s41467-020-16022-0","title":"A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Toronto; Centre for Addiction and Mental Health; University of British Columbia","funders":"National Institute of Mental Health; Biotechnology and Biological Sciences Research Council; China Scholarship Council; Lundbeckfonden; University of Edinburgh; Age UK; Wellcome Trust; Royal College of Physicians of Edinburgh; Medical Research Council; Directorate for Biological Sciences; Wellcome; Sackler Trust; National Alliance for Research on Schizophrenia and Depression","keywords":"Biobank; Phenome; Polygenic risk score; Mendelian inheritance; Depression (economics); Medicine; Association (psychology); Genome-wide association study; Bioinformatics; Biology; Environmental health; Genetics; Single-nucleotide polymorphism; Psychology; Genotype; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004168496,0.0003455194,0.0005517913,0.0009044252,0.0008640586,0.0006402456,0.0007496385,0.0008038362,0.003403939],"category_scores_gemma":[0.02098755,0.0003978103,0.0007113703,0.002072573,0.0005464759,0.0003462349,0.001030713,0.0006800373,0.0004273091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006079169,"about_ca_system_score_gemma":0.0005470307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03673091,"about_ca_topic_score_gemma":0.02697135,"domain_scores_codex":[0.9941806,0.003544785,0.0004741441,0.001094207,0.0004433237,0.0002627944],"domain_scores_gemma":[0.9891729,0.00406536,0.002654258,0.003102811,0.0006496381,0.0003549861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000868732,0.00006372124,0.9860195,0.00007798976,0.001030889,0.0006629158,0.0005842737,0.0004214529,0.00226376,0.0004987978,0.003136207,0.004371827],"study_design_scores_gemma":[0.0001658152,0.0001543344,0.9957085,0.00003901135,0.00029682,0.0005824091,0.0001348738,0.001096003,0.0002545855,0.0002596607,0.001290087,0.00001798946],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99123,0.0002703605,0.003477411,0.0002278067,0.00002421305,0.00008723688,0.004237863,0.00002511574,0.0004199934],"genre_scores_gemma":[0.9941124,0.00009263953,0.002191398,0.000130502,0.00001560941,0.0001676056,0.002673472,0.00001508887,0.000601153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03673091,"threshold_uncertainty_score":0.07303423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852874483749381,"score_gpt":0.3008028459881943,"score_spread":0.2822741011507005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}