{"id":"W3021518689","doi":"10.1002/jcp.29770","title":"Histone H4 variant, H4G, drives ribosomal RNA transcription and breast cancer cell proliferation by loosening nucleolar chromatin structure","year":2020,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Research Grants Council, University Grants Committee","keywords":"Nucleolus; Chromatin; Ribosome biogenesis; Nucleophosmin; Cell biology; Nucleosome; Biology; Transcription (linguistics); Histone; RNA; Cancer research; Molecular biology; Ribosome; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006247985,0.0001467473,0.00009414014,0.0001721022,0.0001372441,0.0001855641,0.0001089449,0.000129428,0.001009436],"category_scores_gemma":[0.00007367307,0.00009583491,0.0001152068,0.0001315441,0.0002158895,0.00007452922,0.0001559325,0.0001793192,0.0001889864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236261,"about_ca_system_score_gemma":0.0001196125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001061728,"about_ca_topic_score_gemma":0.001625092,"domain_scores_codex":[0.9999323,0.00001007344,0.000003738339,0.00001699546,0.00001568745,0.0000211717],"domain_scores_gemma":[0.9999615,0.000003619243,0.00001198743,0.000004369505,0.000004219597,0.0000143339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004870994,0.000005842693,0.001393721,0.00001106255,0.000003825626,0.00002796475,0.000006113806,0.00001770668,0.9976472,0.00003895918,0.00002438138,0.0007745351],"study_design_scores_gemma":[0.00001567061,0.0001799449,0.06831487,0.000004101204,0.00002352258,0.0004146807,0.000117026,0.0009027053,0.926356,0.0001407052,0.003525672,0.000005121785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998033,0.0005362977,0.0006926585,0.00004262462,0.00001342838,0.000004695951,0.0001069042,0.00003250395,0.0005378384],"genre_scores_gemma":[0.9981124,0.0002102823,0.0003099375,0.00001818831,0.000004100675,0.000004747077,0.0002037415,0.000007033505,0.001129686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061728,"threshold_uncertainty_score":0.003376901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00335371691307612,"score_gpt":0.1959443424926277,"score_spread":0.1925906255795515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}