{"id":"W3021518689","doi":"10.1002/jcp.29770","title":"Histone H4 variant, H4G, drives ribosomal RNA transcription and breast cancer cell proliferation by loosening nucleolar chromatin structure","year":2020,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Research Grants Council, University Grants Committee","keywords":"Nucleolus; Chromatin; Ribosome biogenesis; Nucleophosmin; Cell biology; Nucleosome; Biology; Transcription (linguistics); Histone; RNA; Cancer research; Molecular biology; Ribosome; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007239083,0.000178403,0.0002743196,0.00002127292,0.00009240391,0.00002575514,0.0001544524,0.0001898958,0.0000715583],"category_scores_gemma":[0.000009085742,0.0001616328,0.00009630412,0.00004294691,0.00007682294,0.00001765816,0.00004090735,0.0001866231,9.464445e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002662854,"about_ca_system_score_gemma":0.0000780384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000128706,"about_ca_topic_score_gemma":0.000009327643,"domain_scores_codex":[0.9989905,0.00009658894,0.0003986649,0.0002267037,0.0001065443,0.0001809675],"domain_scores_gemma":[0.9992368,0.000005321504,0.0004136218,0.0001064562,0.0001108726,0.00012696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001727499,0.00004393242,0.0001260647,0.00006935902,0.00007171374,0.00000617051,0.0003450382,0.0005554328,0.9972153,0.00001713524,0.0008477024,0.0005294482],"study_design_scores_gemma":[0.00203457,0.0009018727,0.003758608,0.0000282689,0.0001319139,0.000219281,0.000214215,0.007756794,0.9813952,0.000222896,0.002979286,0.0003570744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896198,0.003312822,0.006058712,0.0005791366,0.0001692368,0.0001009959,0.0001249298,0.000004548224,0.00002982667],"genre_scores_gemma":[0.9964442,0.0007023492,0.001698812,0.0003437886,0.0006219872,0.000001757327,0.0001265601,0.00002693454,0.00003357261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01582003,"threshold_uncertainty_score":0.6591193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00335371691307612,"score_gpt":0.1959443424926277,"score_spread":0.1925906255795515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}