{"id":"W3021544380","doi":"10.1002/ctm2.8","title":"Combinatorial assessment of ctDNA release and mutational burden predicts anti‐PD(L)1 therapy outcome in nonsmall‐cell lung cancer","year":2020,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Power Generation; Centre de Développement du Porc du Québec","funders":"Science and Technology Planning Project of Guangdong Province; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Medicine; Liquid biopsy; Immunotherapy; Biomarker; Oncology; Lung cancer; Cancer; Disease; Immune checkpoint; Internal medicine; Circulating tumor cell; Targeted therapy; Bioinformatics; Metastasis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001061033,0.0004021958,0.0004867915,0.0007771035,0.0002593095,0.0009917897,0.0004018626,0.0007055677,0.0006830563],"category_scores_gemma":[0.001963581,0.0002511461,0.0002045247,0.0006479538,0.0003595287,0.000486137,0.0004358114,0.0006717844,0.0003353409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004776091,"about_ca_system_score_gemma":0.0003195062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009005874,"about_ca_topic_score_gemma":0.001315889,"domain_scores_codex":[0.999683,0.00008799432,0.00003141966,0.00008578118,0.00007903505,0.0000327726],"domain_scores_gemma":[0.9990791,0.0003280887,0.0002183386,0.00005090494,0.00009016583,0.0002333817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004615657,0.0004189248,0.9498683,0.0000642952,0.0001070277,0.0001724673,0.00008689298,0.0009219169,0.01087686,0.0000425254,0.0004547672,0.03237037],"study_design_scores_gemma":[0.0001028262,0.002387147,0.9811215,0.00002281631,0.0001935292,0.0006459273,0.0001220946,0.00986251,0.004525375,0.0002194076,0.0007742088,0.00002252586],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974973,0.001490992,0.0002738839,0.0000633215,0.00001330289,0.00002726204,0.0001720856,0.00002286956,0.0004390122],"genre_scores_gemma":[0.998875,0.0002778108,0.0002592478,0.00006509063,0.00001917858,0.00002727373,0.0003135532,0.00000437928,0.0001584803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061033,"threshold_uncertainty_score":0.00561136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03750517155325412,"score_gpt":0.3745775224382067,"score_spread":0.3370723508849526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}