{"id":"W3021579311","doi":"10.1016/j.eururo.2020.04.044","title":"Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients","year":2020,"lang":"en","type":"article","venue":"European Urology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":377,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Labex Immuno-Oncology; European Research Council; European Society for Medical Oncology; Novo Nordisk Fonden; Cancéropôle Ile de France; Institut Universitaire de France; Fondation de France; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Institut Gustave-Roussy; Fondation Leducq; Breast Cancer Research Foundation; European Commission; Association pour la Recherche sur le Cancer; Fondation Philanthropia","keywords":"Medicine; Renal cell carcinoma; Immunotherapy; Carcinoma; Cancer; Bacteria; Primary (astronomy); Kidney cancer; Internal medicine; Oncology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007191598,0.0001235718,0.0001355454,0.00003178912,0.00003727774,0.000009672623,0.0001805905,0.00005416672,0.00002949371],"category_scores_gemma":[0.000005917849,0.0001296833,0.00003472975,0.00006970869,0.00003431374,0.000002696917,0.00009625356,0.0001037926,0.00004265092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002067908,"about_ca_system_score_gemma":0.00004462974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009919699,"about_ca_topic_score_gemma":0.00003543013,"domain_scores_codex":[0.998891,0.0002686866,0.0002078848,0.0003511207,0.00004250771,0.0002388101],"domain_scores_gemma":[0.9996274,0.000004954927,0.00006657949,0.0001738936,0.00003595844,0.0000911738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006270258,0.00005351527,0.01978342,0.00001899532,0.00000520246,0.000009828576,0.0003189667,0.00001951976,0.9718783,0.000004110319,0.006860405,0.0004207269],"study_design_scores_gemma":[0.001059695,0.0005482311,0.8154732,0.000004165992,0.000003512264,8.770515e-7,0.000004212462,0.000001242435,0.02170671,0.000001109883,0.1610583,0.0001388151],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945881,0.0005485236,0.0001110197,0.001676637,0.0001195375,0.0001856824,0.00003768195,0.0000150605,0.002717697],"genre_scores_gemma":[0.984514,0.0001073457,0.0004362108,0.01436454,0.0001890948,0.000005988613,0.0001999003,0.00004175622,0.000141156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9501716,"threshold_uncertainty_score":0.5288332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006717341054477684,"score_gpt":0.2149751329187804,"score_spread":0.2082577918643027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}