{"id":"W3021579311","doi":"10.1016/j.eururo.2020.04.044","title":"Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients","year":2020,"lang":"en","type":"article","venue":"European Urology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":377,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Labex Immuno-Oncology; European Research Council; European Society for Medical Oncology; Novo Nordisk Fonden; Cancéropôle Ile de France; Institut Universitaire de France; Fondation de France; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Institut Gustave-Roussy; Fondation Leducq; Breast Cancer Research Foundation; European Commission; Association pour la Recherche sur le Cancer; Fondation Philanthropia","keywords":"Medicine; Renal cell carcinoma; Immunotherapy; Carcinoma; Cancer; Bacteria; Primary (astronomy); Kidney cancer; Internal medicine; Oncology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002280959,0.000142832,0.0003552479,0.0003598596,0.0004170267,0.0009278212,0.0001495335,0.0004082384,0.002567347],"category_scores_gemma":[0.0009731246,0.0001475194,0.000279249,0.0005524926,0.0002430775,0.0002561708,0.0003806943,0.0004238256,0.000276676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003540178,"about_ca_system_score_gemma":0.0003028302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121081,"about_ca_topic_score_gemma":0.001193959,"domain_scores_codex":[0.9997723,0.00005413442,0.0000129621,0.00005535094,0.0000264395,0.00007881508],"domain_scores_gemma":[0.9996444,0.00006641619,0.0001464819,0.00001948978,0.00003318702,0.00009013067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001332558,0.0001299371,0.9734041,0.00003443168,0.0001185256,0.0004579698,0.0002914251,0.000100452,0.01349434,0.0001478844,0.0002925889,0.0101958],"study_design_scores_gemma":[0.00001269422,0.0002192272,0.9959702,0.00001376231,0.00006979272,0.0008203768,0.0004944724,0.0003013035,0.001271183,0.0001821462,0.000638126,0.000006646772],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992245,0.000279913,0.00003399942,0.00005872826,0.000005128194,0.000001989998,0.00005371731,0.000002862663,0.0003391256],"genre_scores_gemma":[0.9995976,0.00006651569,0.0000269474,0.00004373148,0.000006327912,0.00000154395,0.00005299363,0.000002173555,0.00020226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002567347,"threshold_uncertainty_score":0.008588672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006717341054477684,"score_gpt":0.2149751329187804,"score_spread":0.2082577918643027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}