{"id":"W3021689191","doi":"10.1038/s41408-020-0321-6","title":"Venetoclax for the treatment of translocation (11;14) AL amyloidosis","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Journal","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"National Cancer Institute","keywords":"Chromosomal translocation; Venetoclax; Amyloidosis; AL amyloidosis; Medicine; Internal medicine; Oncology; Cancer research; Leukemia; Immunology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007015306,0.0001745279,0.0002116601,0.00002042244,0.0001464157,0.00002611418,0.0001910296,0.00007619227,0.0000536426],"category_scores_gemma":[0.00002552726,0.0001178259,0.0002888017,0.00007735276,0.00005444453,0.000005091073,0.00001096414,0.00004893793,0.000001609126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000637869,"about_ca_system_score_gemma":0.0002449535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006726233,"about_ca_topic_score_gemma":0.0001249123,"domain_scores_codex":[0.9991022,0.00003940322,0.0002795245,0.0002190747,0.0001444069,0.0002153543],"domain_scores_gemma":[0.9993559,0.00004193963,0.0001933954,0.0001807624,0.0001086818,0.000119293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001386952,0.00153206,0.150451,0.00009790104,0.006133357,0.00001413196,0.002814026,0.005289704,0.6198913,0.0001098116,0.03373658,0.1785432],"study_design_scores_gemma":[0.004806655,0.0022434,0.005779,0.00002477755,0.0007775471,0.00002485944,0.0001878043,0.0001283521,0.7435266,0.00001456464,0.2423041,0.0001822843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9430174,0.03787059,0.002694315,0.01515227,0.0003679745,0.0006818383,0.0001672787,0.00001149995,0.00003679058],"genre_scores_gemma":[0.963836,0.03305813,0.0005616492,0.001335577,0.000762159,0.0003144442,0.00002471855,0.00002992541,0.00007742426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2085676,"threshold_uncertainty_score":0.4804799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02581167300333707,"score_gpt":0.2980678110796958,"score_spread":0.2722561380763587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}