{"id":"W3021777615","doi":"10.1021/acs.bioconjchem.0c00239","title":"An Artificial Amphiphilic Peptide Promotes Endocytic Uptake by Inducing Membrane Curvature","year":2020,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science; Core Research for Evolutional Science and Technology; Institute for Chemical Research, Kyoto University; Japan Agency for Medical Research and Development","keywords":"Endocytic cycle; Endocytosis; Chemistry; Membrane curvature; Membrane; Cell biology; Amphiphile; Biophysics; Vesicle; Cell membrane; Amphiphysin; Cell; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001068725,0.0002948139,0.0002190345,0.000008270391,0.0001074686,0.00006199432,0.0002961243,0.0003613306,0.0002009758],"category_scores_gemma":[0.00004834024,0.0003072798,0.0001337181,0.0001173473,0.00008431975,0.00001099244,0.00003780455,0.0002449323,0.00002052681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001634575,"about_ca_system_score_gemma":0.0000899206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001253183,"about_ca_topic_score_gemma":0.000004633366,"domain_scores_codex":[0.9984224,0.00002427611,0.0003232891,0.0006932084,0.0001821531,0.0003546921],"domain_scores_gemma":[0.9991183,0.000004212187,0.0001044974,0.0003939316,0.00006241088,0.0003166073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000114292,0.00006996442,0.0002608341,0.0001273205,0.0000434671,0.00001332953,0.0001451875,0.000009732266,0.998616,0.00001093733,0.0003192162,0.000269714],"study_design_scores_gemma":[0.0003964299,0.0001142671,0.00005843959,0.00001597498,0.00003775883,0.00001308955,0.000114886,0.0001593838,0.9617612,0.00003563668,0.0369384,0.0003545775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970425,0.0006379021,0.0006509624,0.0007209511,0.00006068182,0.000223222,0.0001155907,0.00007300801,0.0004751658],"genre_scores_gemma":[0.9883153,0.00007077069,0.0001342573,0.0004793626,0.0008913394,0.00002315689,0.009844268,0.00005029926,0.000191221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03685484,"threshold_uncertainty_score":0.999938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546914355107316,"score_gpt":0.2272741210434656,"score_spread":0.2118049774923925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}