{"id":"W3021777615","doi":"10.1021/acs.bioconjchem.0c00239","title":"An Artificial Amphiphilic Peptide Promotes Endocytic Uptake by Inducing Membrane Curvature","year":2020,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science; Core Research for Evolutional Science and Technology; Institute for Chemical Research, Kyoto University; Japan Agency for Medical Research and Development","keywords":"Endocytic cycle; Endocytosis; Chemistry; Membrane curvature; Membrane; Cell biology; Amphiphile; Biophysics; Vesicle; Cell membrane; Amphiphysin; Cell; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689786,0.0002759039,0.0001915982,0.00009076032,0.0000915475,0.0002070227,0.0001338302,0.0003446458,0.0003868384],"category_scores_gemma":[0.0001222577,0.00009080032,0.000198343,0.00009937052,0.0002207717,0.00021683,0.0002733719,0.0003836702,0.0002098447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001491334,"about_ca_system_score_gemma":0.0001136368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001343656,"about_ca_topic_score_gemma":0.000150459,"domain_scores_codex":[0.9998902,0.00003243747,0.00001100302,0.00001621393,0.00002784417,0.00002226739],"domain_scores_gemma":[0.9998838,0.00002848565,0.00003485378,0.00001095399,0.00001284898,0.00002910682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001730482,0.000003585198,0.00001916466,0.00001161477,9.117036e-7,0.00002266449,0.000004234294,0.0000252107,0.9996639,0.00003428325,0.000003882888,0.0001932252],"study_design_scores_gemma":[0.000007290922,0.0001302231,0.0005226652,0.000002424204,0.00000310043,0.0001444883,0.000005673607,0.0005609171,0.9979724,0.00002066594,0.000626081,0.000004013923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955096,0.0004704062,0.003259933,0.00005017182,0.00001039671,0.00002729283,0.0000488107,0.00003380667,0.0005896165],"genre_scores_gemma":[0.9945703,0.0003409112,0.004397103,0.00004415576,0.000005341117,0.00002048205,0.000084556,0.0000132997,0.0005238075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003868384,"threshold_uncertainty_score":0.001294076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546914355107316,"score_gpt":0.2272741210434656,"score_spread":0.2118049774923925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}