{"id":"W3021781431","doi":"10.1016/j.chembiol.2020.04.006","title":"Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institutes of Health","keywords":"Lipid bilayer fusion; Peptide; Viral entry; Viral envelope; Virology; Glycoprotein; Chemistry; Fusion protein; Hepatitis C virus; Entry inhibitor; Mutant; Molecular biology; Biology; Virus; Recombinant DNA; Biochemistry; Viral replication; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009588747,0.0003037025,0.0002715124,0.0001833904,0.00020366,0.0002621913,0.0002411705,0.0002607651,0.002061759],"category_scores_gemma":[0.0001794075,0.0001186407,0.0001638755,0.0001575351,0.0002915587,0.0001080074,0.0001378904,0.0004516573,0.0003258767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005657718,"about_ca_system_score_gemma":0.0005881097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004607109,"about_ca_topic_score_gemma":0.007679452,"domain_scores_codex":[0.999878,0.00002694499,0.000005249583,0.00001086935,0.00001880034,0.00005999207],"domain_scores_gemma":[0.9999518,0.00001760642,0.000008028001,0.000003942458,0.00000571127,0.00001293622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001748075,0.0001596227,0.0003917122,0.0001112162,0.00001900503,0.0001059517,0.00004022126,0.0004862086,0.9888447,0.0005611323,0.0005668119,0.00696533],"study_design_scores_gemma":[0.0004696794,0.002745247,0.004044772,0.00001106971,0.00002429724,0.0002960781,0.00005256915,0.001680895,0.9853974,0.00007821815,0.00518286,0.00001695828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919392,0.001919141,0.0008555846,0.0002107808,0.00006561296,0.00005685378,0.0002285112,0.0001055571,0.004618615],"genre_scores_gemma":[0.9969307,0.000747211,0.000439821,0.0000399109,0.00001388843,0.00001947242,0.000187222,0.00000659329,0.001615164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004607109,"threshold_uncertainty_score":0.009160578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669972047653709,"score_gpt":0.2706727056023642,"score_spread":0.2539729851258271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}