{"id":"W3021781431","doi":"10.1016/j.chembiol.2020.04.006","title":"Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institutes of Health","keywords":"Lipid bilayer fusion; Peptide; Viral entry; Viral envelope; Virology; Glycoprotein; Chemistry; Fusion protein; Hepatitis C virus; Entry inhibitor; Mutant; Molecular biology; Biology; Virus; Recombinant DNA; Biochemistry; Viral replication; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001732614,0.0002341987,0.0006035679,0.00005899255,0.00004244691,0.000006897542,0.0002144359,0.0003761739,0.00133548],"category_scores_gemma":[0.000975802,0.0002068582,0.000124186,0.000295833,0.000279229,0.00004275759,0.0003212549,0.0005471501,0.0002873134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008053706,"about_ca_system_score_gemma":0.000103999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007003751,"about_ca_topic_score_gemma":0.000006985039,"domain_scores_codex":[0.9979821,0.000111357,0.000569256,0.0005388646,0.0002608583,0.0005375134],"domain_scores_gemma":[0.9989649,0.0001413492,0.0001354644,0.000217677,0.0001229952,0.0004176235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003640712,0.0001367357,0.02259641,0.0001887564,0.00002312882,0.00002809015,0.0001253285,9.938033e-8,0.9509256,0.00001735933,0.01173445,0.01386001],"study_design_scores_gemma":[0.00123938,0.0004430151,0.0001008269,0.00004269198,0.00001679002,0.000001950169,0.000007262542,0.0001510336,0.9138983,0.00003746245,0.08388752,0.0001737705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981952,0.001482744,0.0001127528,0.001622931,0.0000686131,0.0004530783,0.0001368473,0.00008883234,0.01408227],"genre_scores_gemma":[0.995131,0.001382891,0.001225029,0.001126839,0.0002947149,0.00003563918,0.0005581556,0.00003859482,0.0002071996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07215308,"threshold_uncertainty_score":0.9995775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669972047653709,"score_gpt":0.2706727056023642,"score_spread":0.2539729851258271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}