{"id":"W3021799134","doi":"10.1136/gutjnl-2019-bsgabstracts.307","title":"OWE-16 Development and clinical validation of a genetic risk score for coeliac disease","year":2019,"lang":"en","type":"article","venue":"","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Single-nucleotide polymorphism; Genome-wide association study; Coeliac disease; Medicine; Imputation (statistics); Internal medicine; Cohort; Odds ratio; Haplotype; Human leukocyte antigen; HLA-DQ; Population; Receiver operating characteristic; Genotype; Oncology; Genetics; Disease; Biology; Immunology; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005543604,0.0006122377,0.000641413,0.001683356,0.000363635,0.001202116,0.0005078447,0.0006917205,0.002563898],"category_scores_gemma":[0.01131143,0.0002366405,0.0007551181,0.001118609,0.0005241752,0.0004980578,0.001546407,0.0005542004,0.0007833007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004580666,"about_ca_system_score_gemma":0.000472567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00188564,"about_ca_topic_score_gemma":0.001887075,"domain_scores_codex":[0.9977236,0.0009719292,0.0003759217,0.0003726884,0.0003653846,0.0001904137],"domain_scores_gemma":[0.9946555,0.001738412,0.00136642,0.0004607636,0.00118209,0.0005969002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008813545,0.00008019732,0.9803014,0.00006225192,0.0001790877,0.0001469815,0.0001453767,0.0006667761,0.001720266,0.0001958579,0.0007914203,0.01482901],"study_design_scores_gemma":[0.0002962232,0.00104395,0.9870976,0.00007942458,0.0001714164,0.0009523803,0.0001896502,0.004725031,0.001631451,0.0005340308,0.003249198,0.00002950777],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940754,0.0003270429,0.001975354,0.0001588832,0.00003086564,0.000137141,0.001861093,0.00002884758,0.001405484],"genre_scores_gemma":[0.9885986,0.0001131203,0.006715888,0.00006736675,0.00003399377,0.0001364741,0.003227936,0.00002060034,0.001086067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005543604,"threshold_uncertainty_score":0.02931774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04287647037154582,"score_gpt":0.3662834884049636,"score_spread":0.3234070180334178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}