{"id":"W3021823482","doi":"10.1016/j.ijbiomac.2020.05.048","title":"Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction","year":2020,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; University of Alberta","funders":"Alberta Innovates Bio Solutions; Natural Sciences and Engineering Research Council of Canada; Alberta Livestock and Meat Agency; Canada Research Chairs; Alberta Crop Industry Development Fund","keywords":"Chitosan; CpG Oligodeoxynucleotide; Intracellular; Chemistry; Drug delivery; In vitro; Acetylation; Mannose; Biophysics; Biochemistry; Biology; Gene expression; Organic chemistry; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515148,0.0003115836,0.0001756461,0.0001328614,0.0001123397,0.0002020612,0.0001426753,0.0002425326,0.0004638545],"category_scores_gemma":[0.0001828247,0.000129379,0.0001805005,0.000133098,0.0002081624,0.0001835529,0.0001028555,0.0002954632,0.00011076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004026548,"about_ca_system_score_gemma":0.0003260688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001911173,"about_ca_topic_score_gemma":0.003207386,"domain_scores_codex":[0.9999187,0.0000106882,0.000008307742,0.00001701541,0.00002461665,0.00002062449],"domain_scores_gemma":[0.9999044,0.00002161018,0.00002990766,0.000006334873,0.00001975617,0.00001799121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008898509,0.000008342957,0.00002892294,0.00002069077,0.000002250648,0.000008650098,0.000005246564,0.00005646347,0.9991316,0.00002879055,0.000008695422,0.0006113469],"study_design_scores_gemma":[0.000006756483,0.0001174128,0.0002458983,0.000001341013,0.00001051335,0.00001693875,0.000002546299,0.0003883917,0.9989766,0.000007839242,0.0002227865,0.000002973285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935368,0.001376386,0.004037107,0.00008132894,0.0000309982,0.00004366504,0.000104264,0.00004077411,0.0007486367],"genre_scores_gemma":[0.9949863,0.0005898452,0.003172976,0.00003403995,0.000007179,0.00002657828,0.00008082024,0.00001487714,0.001087424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001911173,"threshold_uncertainty_score":0.003800094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02304084679906208,"score_gpt":0.2658531769674544,"score_spread":0.2428123301683923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}