{"id":"W3021856761","doi":"10.1038/s41467-020-16038-6","title":"A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Research Foundation; Weill Cornell Medical College; March of Dimes Canada; U.S. Department of Health and Human Services; National Institutes of Health; Pershing Square Sohn Cancer Research Alliance; March of Dimes Foundation; Burroughs Wellcome Fund; National Research Foundation of Korea; U.S. Department of Defense","keywords":"RUNX2; Cell biology; Deubiquitinating enzyme; Ubiquitin; Signal transduction; Regulator; Biology; Chemistry; Osteoblast; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003273308,0.0006337732,0.0002867879,0.0004284738,0.0003942387,0.0004931082,0.0002670748,0.000428064,0.001930673],"category_scores_gemma":[0.0002064544,0.000209512,0.0003493027,0.0001606524,0.0005961299,0.0003234618,0.0004896949,0.0005223951,0.0004704301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004592637,"about_ca_system_score_gemma":0.0004196045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003530838,"about_ca_topic_score_gemma":0.0007813163,"domain_scores_codex":[0.9997249,0.00003681923,0.00002079602,0.00005863217,0.00009116263,0.0000676654],"domain_scores_gemma":[0.9998763,0.00001042782,0.00004752775,0.00001537257,0.000013238,0.00003718061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003166914,0.00003099434,0.001548261,0.0001381732,0.0000248143,0.0006086142,0.00003704806,0.000192573,0.9889269,0.001781786,0.0002506722,0.006143537],"study_design_scores_gemma":[0.00006009531,0.0003324844,0.02492695,0.00002771558,0.00006306013,0.003559386,0.000139214,0.002098008,0.9514762,0.001857794,0.01544414,0.00001485873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9494411,0.02383685,0.01416466,0.0009356536,0.0001632199,0.00006878996,0.0006659694,0.0004824252,0.01024145],"genre_scores_gemma":[0.992392,0.002693901,0.001225021,0.00007476592,0.00003161998,0.0000339609,0.0002269726,0.0000194972,0.003302323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930673,"threshold_uncertainty_score":0.006458759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04371810819880997,"score_gpt":0.3035545373498577,"score_spread":0.2598364291510477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}