{"id":"W3021863050","doi":"10.1016/j.ajhg.2020.04.004","title":"Insufficient Evidence for “Autism-Specific” Genes","year":2020,"lang":"en","type":"review","venue":"The American Journal of Human Genetics","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":169,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Human Genome Research Institute; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Mental Health; Fondation Bettencourt Schueller; Université de Paris; Simons Foundation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Simons Foundation Autism Research Initiative; Howard Hughes Medical Institute","keywords":"Autism; Gene; Genetics; Biology; Computational biology; Psychology; Evolutionary biology; Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002231719,0.001473631,0.003214018,0.00257034,0.0003153416,0.001445424,0.002071024,0.002791558,0.005129936],"category_scores_gemma":[0.004101207,0.0003746186,0.001009409,0.001850805,0.001649044,0.002009987,0.001170699,0.002869993,0.002097859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00111162,"about_ca_system_score_gemma":0.00269244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001462896,"about_ca_topic_score_gemma":0.002732912,"domain_scores_codex":[0.9994548,0.0001302515,0.00009515077,0.0001354204,0.0001461692,0.00003814656],"domain_scores_gemma":[0.9975562,0.001757924,0.0001695247,0.00007007367,0.0003277736,0.0001184499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001863488,0.00002843287,0.0004220663,0.02721073,0.0003705922,0.0004149392,0.00004184909,0.0002401055,0.001015161,0.01160251,0.120298,0.8381693],"study_design_scores_gemma":[0.00007715573,0.00006011434,0.001154046,0.01697104,0.0006672005,0.001776624,0.00008080517,0.00006962374,0.000303939,0.009469421,0.969334,0.00003606212],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000300113,0.9979424,0.00008103392,0.0009031206,0.0005859415,0.000001299514,0.00002233105,0.000005773375,0.0004280824],"genre_scores_gemma":[0.0003711996,0.9973163,0.0001672473,0.001127585,0.0007390902,0.000004155364,0.00005111144,0.000002826579,0.0002204582],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005129936,"threshold_uncertainty_score":0.01716131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2573601830150787,"score_gpt":0.4409503416730024,"score_spread":0.1835901586579237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}