{"id":"W3021883334","doi":"10.1101/2020.05.06.076745","title":"Functional brain age prediction suggests accelerated aging in preclinical familial Alzheimer’s disease, irrespective of fibrillar amyloid-beta pathology","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Pfizer Canada; Genentech; National Institutes of Health; Fleni; IXICO; Servier; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Canada Research Chairs; Government of Canada; Réseau en Bio-Imagerie du Quebec; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; McGill University; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer Society; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Disease; Context (archaeology); Brain aging; Asymptomatic; Amyloid (mycology); Neuroscience; BETA (programming language); Medicine; Alzheimer's disease; Amyloid beta; Pathology; Psychology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004943148,0.0003356369,0.0001910526,0.0004590523,0.00009923852,0.0002730437,0.0002085486,0.000236132,0.0009866294],"category_scores_gemma":[0.001363242,0.00009660934,0.0002634166,0.0001660306,0.0002111523,0.0002686813,0.0001724368,0.0002301918,0.0001236745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049514,"about_ca_system_score_gemma":0.0001989855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002175521,"about_ca_topic_score_gemma":0.00239582,"domain_scores_codex":[0.9999111,0.00003050821,0.00000364139,0.00003709439,0.000008518237,0.000009203791],"domain_scores_gemma":[0.9995963,0.0002058139,0.00009455108,0.00004501452,0.00002810224,0.0000303282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001516658,0.0004641595,0.7312525,0.0001052592,0.0004924368,0.0006358646,0.0003528268,0.1640479,0.0582569,0.005090924,0.001422392,0.03636223],"study_design_scores_gemma":[0.00003031432,0.0004123895,0.5236108,0.00001366689,0.00008147446,0.0006327583,0.00008936552,0.459639,0.004188927,0.0108422,0.0004346591,0.00002447014],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880986,0.00005300862,0.01110344,0.00006801373,0.00000547364,0.000005744313,0.0002490631,0.00004315521,0.000373533],"genre_scores_gemma":[0.9986051,0.00002192322,0.001144565,0.000005176953,0.000002703966,0.000004537096,0.0001315179,0.000002977734,0.00008148292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002175521,"threshold_uncertainty_score":0.004325688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08539303320516477,"score_gpt":0.293749982670704,"score_spread":0.2083569494655392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}