{"id":"W3021927596","doi":"10.3389/fonc.2020.00636","title":"Deregulation of Adaptive T Cell Immunity in Multiple Myeloma: Insights Into Mechanisms and Therapeutic Opportunities","year":2020,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Immune system; Immunotherapy; Stromal cell; Multiple myeloma; Immunology; Medicine; Bone marrow; Disease; Cancer research; Immunity; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004177526,0.0005914828,0.0009609853,0.001424108,0.0001923797,0.0007349472,0.0005379628,0.0008119792,0.002340359],"category_scores_gemma":[0.0003756303,0.0001797393,0.0003939517,0.001437788,0.0003271389,0.0009131648,0.0005293455,0.001362792,0.001161206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004686865,"about_ca_system_score_gemma":0.0009242019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006321086,"about_ca_topic_score_gemma":0.001291384,"domain_scores_codex":[0.9998959,0.00001919413,0.00001211783,0.00001674998,0.00004090412,0.00001502203],"domain_scores_gemma":[0.9998492,0.00006519072,0.00002224165,0.000004640717,0.00004148765,0.00001722577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001094537,0.00008157826,0.0001693628,0.01917106,0.00009640461,0.000234775,0.00006810913,0.0004101745,0.004191531,0.004422632,0.0194704,0.9515744],"study_design_scores_gemma":[0.00003006844,0.0001914781,0.001016126,0.004079605,0.0001482081,0.001342997,0.00007416766,0.0001278074,0.0009345232,0.002726762,0.9893114,0.00001676662],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001383653,0.9988129,0.00009250326,0.0002328188,0.0001128618,0.000002841353,0.00001132591,0.000005206259,0.000591172],"genre_scores_gemma":[0.0006409537,0.9986816,0.0001168722,0.0001373284,0.00008664266,0.000003425555,0.0000169846,6.873511e-7,0.0003155318],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002340359,"threshold_uncertainty_score":0.007829249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.109972644878723,"score_gpt":0.3503485907757205,"score_spread":0.2403759458969975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}