{"id":"W3021996333","doi":"10.3390/cancers12051148","title":"A Novel 4-gene Score to Predict Survival, Distant Metastasis and Response to Neoadjuvant Therapy in Breast Cancer","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Susan G. Komen; University of Toronto; Sunnybrook Research Institute; Roswell Park Cancer Institute; Susan G. Komen for the Cure","keywords":"Medicine; Oncology; Internal medicine; Breast cancer; Hazard ratio; Cohort; Proportional hazards model; Biomarker; Chemotherapy; Framingham Risk Score; Hormonal therapy; Pathological; Neoadjuvant therapy; Cancer; Disease; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004433361,0.0007315539,0.000563778,0.001748142,0.0001650796,0.000483114,0.0003109619,0.0003202537,0.001560746],"category_scores_gemma":[0.001173228,0.0001160795,0.0006101121,0.0009555225,0.000268128,0.0002541954,0.0005171892,0.0003466328,0.0003247558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003725862,"about_ca_system_score_gemma":0.0004273152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008878802,"about_ca_topic_score_gemma":0.001570298,"domain_scores_codex":[0.9996971,0.00006628345,0.00002468818,0.00005119741,0.00009731251,0.00006346653],"domain_scores_gemma":[0.9995211,0.0001253223,0.0001642893,0.00002181751,0.000084316,0.00008306851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00201129,0.0003741276,0.8586959,0.0001654747,0.0005429971,0.000455979,0.00006167636,0.01153398,0.05978642,0.0003689855,0.001678528,0.0643245],"study_design_scores_gemma":[0.0002979116,0.002690723,0.8890967,0.00004269375,0.0006642361,0.001287492,0.0001396122,0.07233507,0.02568922,0.002373905,0.005271663,0.0001108104],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927018,0.0002627413,0.004407669,0.0001190289,0.00003117674,0.0000724769,0.001595834,0.00007179644,0.0007375574],"genre_scores_gemma":[0.9853036,0.0001238686,0.009512857,0.00007302279,0.00004925975,0.0001214065,0.003932434,0.00002072798,0.0008628786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748142,"threshold_uncertainty_score":0.005221248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04454499954362891,"score_gpt":0.2999552613014491,"score_spread":0.2554102617578202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}