{"id":"W3022025532","doi":"10.1007/s12630-020-01684-7","title":"Post-exposure prophylaxis or pre-emptive therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): study protocol for a pragmatic randomized-controlled trial","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Anesthesia/Journal canadien d anesthésie","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; St. Boniface Hospital; McGill University; Institute of Infection and Immunity; McGill University Health Centre; Université Laval; University of Alberta; University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; National Institute of Mental Health","keywords":"Medicine; Hydroxychloroquine; Randomized controlled trial; Asymptomatic; Clinical trial; Placebo; Pandemic; Intensive care; Intensive care medicine; Severity of illness; Internal medicine; Pediatrics; Disease; Coronavirus disease 2019 (COVID-19); Pathology; Alternative medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03997157,0.008999477,0.01568791,0.002631993,0.003509555,0.005111287,0.004192659,0.009742648,0.08415306],"category_scores_gemma":[0.04054361,0.004188164,0.006791575,0.003734113,0.004984816,0.005411984,0.002637138,0.009293443,0.015543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005207967,"about_ca_system_score_gemma":0.01633209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002087656,"about_ca_topic_score_gemma":0.00420418,"domain_scores_codex":[0.9735916,0.01715821,0.002514256,0.002132237,0.002161974,0.002441776],"domain_scores_gemma":[0.9826745,0.005637398,0.003436221,0.002245869,0.0031812,0.00282489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9273403,0.008517941,0.0004735934,0.02172321,0.002237536,0.0002398005,0.0003170627,0.001450262,0.001133556,0.004152421,0.01436307,0.0180513],"study_design_scores_gemma":[0.9650523,0.01299008,0.0005848175,0.002231441,0.0006320829,0.00003773702,0.00006666608,0.001071878,0.0002611158,0.002097393,0.01490764,0.00006684133],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001297791,0.0003511835,0.001035136,0.0002401615,0.0004278892,0.9951926,0.0008145617,0.00007456704,0.0005660796],"genre_scores_gemma":[0.001587286,0.0001571043,0.00133251,0.0001942231,0.00006458229,0.9962528,0.0001228713,0.000005182021,0.0002834249],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.08415306,"threshold_uncertainty_score":0.28152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05925380243820922,"score_gpt":0.3882344277175698,"score_spread":0.3289806252793606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}