{"id":"W3022099401","doi":"10.1007/s11064-020-03019-w","title":"Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network","year":2020,"lang":"en","type":"article","venue":"Neurochemical Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; University of Manchester; Alzheimer Society; Wellcome Trust","keywords":"Cell biology; Induced pluripotent stem cell; Biology; Exosome; Microvesicles; microRNA; Biochemistry; Embryonic stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377641,0.000259242,0.0001750158,0.0003295914,0.0001555031,0.0003138118,0.00009262485,0.0001903963,0.000644824],"category_scores_gemma":[0.0001558725,0.00008859348,0.0002427507,0.0002004381,0.0001630876,0.0002114343,0.0002813835,0.000260642,0.0003122771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336593,"about_ca_system_score_gemma":0.0001546162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002135025,"about_ca_topic_score_gemma":0.0002968204,"domain_scores_codex":[0.9998994,0.00001088882,0.00001190257,0.00002568002,0.00003619717,0.0000158217],"domain_scores_gemma":[0.9999417,0.00001554753,0.0000126858,0.000006078214,0.00001591075,0.000008143756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003375253,0.000003519037,0.0004574426,0.00004851181,0.000009961541,0.00006048129,0.00001891894,0.00004827027,0.9973164,0.0001517314,0.00002412346,0.001826808],"study_design_scores_gemma":[0.00000636909,0.00009845087,0.0224924,0.00002946931,0.00005897284,0.0007853722,0.00008616775,0.0006928199,0.9680954,0.0003252231,0.007320467,0.000008831988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690444,0.005945504,0.01877401,0.0001677328,0.00006110159,0.00007618704,0.002683101,0.00008686399,0.003161071],"genre_scores_gemma":[0.9817196,0.003201546,0.007047033,0.00009503615,0.00001987855,0.00008030323,0.005341819,0.00003896862,0.002455896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000644824,"threshold_uncertainty_score":0.002157152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06887982658187486,"score_gpt":0.3118920688252441,"score_spread":0.2430122422433693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}