{"id":"W30221314","doi":"10.4137/geg.s3992","title":"UHRF1 Links the Histone Code and DNA Methylation to Ensure Faithful Epigenetic Memory Inheritance","year":2009,"lang":"en","type":"article","venue":"Genetics & Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institutes of Health; National Cancer Institute; Ligue Contre le Cancer","keywords":"Histone methylation; Histone code; Epigenomics; Biology; Epigenetics; Genetics; DNA methylation; Histone; Cancer epigenetics; Histone methyltransferase; Computational biology; Cell biology; DNA; Nucleosome; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005001868,0.0002495711,0.0003826312,0.0002569724,0.0004506544,0.0006663451,0.0004328767,0.0007966991,0.00141581],"category_scores_gemma":[0.0005842416,0.0001886753,0.0003006559,0.000173468,0.0006816988,0.0009148883,0.0006031972,0.0006594172,0.001305193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006623022,"about_ca_system_score_gemma":0.0004146452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008934193,"about_ca_topic_score_gemma":0.0008870427,"domain_scores_codex":[0.9997824,0.00002581806,0.00001264403,0.00005261804,0.00005844673,0.00006820309],"domain_scores_gemma":[0.9998202,0.00002874142,0.00005747756,0.00002448319,0.00003044263,0.00003876703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008229914,0.00001291405,0.001563081,0.0002323266,0.00001764096,0.0003983487,0.0001671754,0.0006268516,0.9238558,0.01258482,0.0009908315,0.059468],"study_design_scores_gemma":[0.00002476622,0.0002496988,0.01333555,0.00007402095,0.00003831319,0.002106226,0.0002235199,0.002231608,0.8755904,0.008887485,0.09717427,0.00006425939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7603498,0.08000452,0.1230664,0.00505267,0.0006862151,0.00008562026,0.0006642949,0.001492332,0.02859808],"genre_scores_gemma":[0.9529679,0.01080928,0.0255289,0.0004894768,0.0001981739,0.00002079525,0.0002708523,0.00007073924,0.009643955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141581,"threshold_uncertainty_score":0.004805326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430073245106564,"score_gpt":0.2841547490443019,"score_spread":0.2698540165932363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}