{"id":"W3022205379","doi":"10.1021/acsnano.9b09773","title":"Monosized Polymeric Microspheres Designed for Passive Lung Targeting: Biodistribution and Pharmacokinetics after Intravenous Administration","year":2020,"lang":"en","type":"article","venue":"ACS Nano","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Lundbeckfonden; Canada Foundation for Innovation","keywords":"Biodistribution; PLGA; In vivo; Pharmacokinetics; Pharmacology; Lung; Materials science; Biomedical engineering; In vitro; Chemistry; Medicine; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004905703,0.0001243051,0.0001726979,0.00002236704,0.00008868877,0.0000304953,0.00003222672,0.00008636565,0.00008477784],"category_scores_gemma":[0.00009212868,0.0001100502,0.00004940073,0.0001190514,0.0000543993,0.00005697289,0.00001499066,0.0000705489,0.00001049765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002998339,"about_ca_system_score_gemma":0.00009775788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001846024,"about_ca_topic_score_gemma":2.464665e-7,"domain_scores_codex":[0.9992721,0.0000318892,0.0002263574,0.0002065569,0.00009862075,0.0001644808],"domain_scores_gemma":[0.999545,0.00004334953,0.00009041568,0.00006485626,0.0001187663,0.0001376333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001665471,0.00007329827,0.0008596712,0.0001474279,0.00005152436,0.00003437687,0.0003655171,0.0000024373,0.9859152,0.00002288364,0.006423546,0.004438639],"study_design_scores_gemma":[0.002770164,0.0005643924,0.0009465521,0.00002543552,0.0001846231,0.00001807269,0.0001384188,0.001205343,0.983956,0.000003963004,0.01002632,0.0001607244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856811,0.001577029,0.008667914,0.003024293,0.0001121611,0.0007294759,0.00007954907,0.00006482278,0.00006365975],"genre_scores_gemma":[0.9955763,0.00008722507,0.001116546,0.002665915,0.0002510347,0.00005257045,0.0001577238,0.00001583378,0.00007681402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009895244,"threshold_uncertainty_score":0.4487715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257780347898135,"score_gpt":0.2636209227229849,"score_spread":0.2510431192440035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}