{"id":"W3022205379","doi":"10.1021/acsnano.9b09773","title":"Monosized Polymeric Microspheres Designed for Passive Lung Targeting: Biodistribution and Pharmacokinetics after Intravenous Administration","year":2020,"lang":"en","type":"article","venue":"ACS Nano","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Lundbeckfonden; Canada Foundation for Innovation","keywords":"Biodistribution; PLGA; In vivo; Pharmacokinetics; Pharmacology; Lung; Materials science; Biomedical engineering; In vitro; Chemistry; Medicine; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002361669,0.0003541442,0.0002233661,0.0001792847,0.00009058351,0.0002559508,0.0001802004,0.0003203716,0.0003675366],"category_scores_gemma":[0.0002365789,0.0001428354,0.0001243671,0.0001139289,0.0002004422,0.0002217568,0.0001039885,0.0003663859,0.0002150091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003900584,"about_ca_system_score_gemma":0.0003355364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009968622,"about_ca_topic_score_gemma":0.001207222,"domain_scores_codex":[0.9998716,0.00002338106,0.000008540816,0.00003666799,0.0000391674,0.00002050063],"domain_scores_gemma":[0.9998776,0.00002404365,0.00004402333,0.000007874152,0.000027813,0.00001870547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006100388,0.0000105293,0.00008946037,0.00004646028,0.00000425543,0.00002139539,0.0000105271,0.0001263833,0.9952427,0.0001186756,0.00005456059,0.00421399],"study_design_scores_gemma":[0.00001240721,0.0003105974,0.0008971994,0.000003925237,0.00001465197,0.0001148608,0.000005935563,0.001405466,0.9938507,0.00003459478,0.003342348,0.000007264078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8855439,0.01663818,0.0930122,0.0003424753,0.0001317933,0.0002815216,0.0004647123,0.0007505045,0.002834705],"genre_scores_gemma":[0.9638533,0.00258007,0.02963308,0.0001135699,0.00003299913,0.0002122416,0.0002859909,0.00007309163,0.003215547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009968622,"threshold_uncertainty_score":0.002830029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257780347898135,"score_gpt":0.2636209227229849,"score_spread":0.2510431192440035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}