{"id":"W3022210979","doi":"10.1002/ijc.33013","title":"Efficacy and safety of pembrolizumab for the treatment of advanced biliary cancer: Results from the <scp>KEYNOTE</scp>‐158 and <scp>KEYNOTE</scp>‐028 studies","year":2020,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":498,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Pembrolizumab; Medicine; Cancer; Cancer research; Internal medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00514854,0.0005098853,0.0009983049,0.0003501411,0.0002383921,0.000976475,0.0004181604,0.0006694618,0.001555434],"category_scores_gemma":[0.00284639,0.000243954,0.001093266,0.0004134659,0.0004072036,0.0008033453,0.0003763127,0.001262136,0.0003384313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00069182,"about_ca_system_score_gemma":0.000575848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000522905,"about_ca_topic_score_gemma":0.001397517,"domain_scores_codex":[0.9989108,0.0005710937,0.0001444787,0.0001196007,0.0001644561,0.00008957901],"domain_scores_gemma":[0.9980293,0.0006282206,0.0007327851,0.0001729859,0.0002091096,0.0002275451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2802937,0.008685634,0.07254437,0.007378309,0.009726587,0.0004690193,0.0005848552,0.003514435,0.07779583,0.0004291639,0.007406629,0.5311714],"study_design_scores_gemma":[0.152643,0.3122019,0.4560294,0.001286998,0.01353663,0.002755855,0.0003866598,0.002814108,0.02259597,0.0008458303,0.0347428,0.0001608171],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536206,0.03996351,0.0004128127,0.000770185,0.00006029282,0.000438205,0.001438774,0.00003531526,0.003260405],"genre_scores_gemma":[0.9902969,0.006598399,0.0004288617,0.0005736201,0.00007941852,0.0001758713,0.001442252,0.00001137164,0.0003931886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00514854,"threshold_uncertainty_score":0.02722842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04428015818870525,"score_gpt":0.3468712392548823,"score_spread":0.302591081066177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}