{"id":"W3022265443","doi":"10.1136/gutjnl-2020-320726","title":"Comprehensive characterisation of pancreatic ductal adenocarcinoma with microsatellite instability: histology, molecular pathology and clinical implications","year":2020,"lang":"en","type":"review","venue":"Gut","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding","keywords":"Microsatellite instability; KRAS; Pancreatic cancer; Adenocarcinoma; Medicine; Oncology; DNA mismatch repair; Internal medicine; Cancer; Pathology; Colorectal cancer; Cancer research; Biology; Microsatellite; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005444713,0.0005922514,0.003550584,0.009761864,0.0002507642,0.001615881,0.0007742676,0.0007381847,0.00114325],"category_scores_gemma":[0.0212086,0.0003660333,0.002676664,0.009930425,0.0005767027,0.001307848,0.0007434655,0.0003589272,0.0002008471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005735335,"about_ca_system_score_gemma":0.002273477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001988569,"about_ca_topic_score_gemma":0.005053873,"domain_scores_codex":[0.9947374,0.001175306,0.002562473,0.0006831384,0.000744403,0.00009718601],"domain_scores_gemma":[0.9739729,0.01447814,0.007498616,0.000788691,0.003023265,0.0002383844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0008077769,0.00003528559,0.05523638,0.6929925,0.02077521,0.0005812465,0.0004779124,0.0003607536,0.004116495,0.0004369275,0.002760427,0.221419],"study_design_scores_gemma":[0.0004415335,0.001383881,0.3001097,0.4690428,0.1284376,0.01166315,0.001868631,0.0004285634,0.003117112,0.001630877,0.0816685,0.0002074944],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008049504,0.9902571,0.0002515987,0.0001750324,0.00004592802,0.00004379383,0.0009249353,0.000005020285,0.0002470679],"genre_scores_gemma":[0.1815202,0.8130054,0.002240765,0.000608165,0.0002675843,0.0001808623,0.001975398,0.00001422162,0.0001873047],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009761864,"threshold_uncertainty_score":0.02879477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07100137629708692,"score_gpt":0.3655731843514809,"score_spread":0.294571808054394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}