{"id":"W3022284000","doi":"10.1210/jendso/bvaa046.639","title":"SAT-402 Investigating Analogues of Parathyroid Hormone (PTH) and PTH-Related Peptide (PTHrP) to Improve Anabolic: Catabolic Response Ratios Using UMR106-01 Osteocytic Cells","year":2020,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Bone health and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Parathyroid hormone; Bone resorption; Endocrinology; Internal medicine; Anabolism; Chemistry; RANKL; Osteoporosis; Osteoclast; Bone mineral; Teriparatide; Catabolism; Osteocyte; Sclerostin; Stimulation; Osteoblast; Receptor; Medicine; Wnt signaling pathway; Biochemistry; Signal transduction; Calcium; In vitro; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000388838,0.0004910431,0.0005471404,0.0003319466,0.000183759,0.0004658303,0.0003118796,0.000637309,0.002743716],"category_scores_gemma":[0.0002162416,0.0001645933,0.0004956219,0.0004709631,0.000189664,0.0001672604,0.0002183263,0.0008884802,0.0008242017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222347,"about_ca_system_score_gemma":0.0001978108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000541352,"about_ca_topic_score_gemma":0.0009147819,"domain_scores_codex":[0.9995325,0.00008330055,0.00006430059,0.00008709449,0.0001740898,0.00005873196],"domain_scores_gemma":[0.9998257,0.00004821616,0.00003296898,0.00001912026,0.00003208441,0.00004191146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000318638,0.000221579,0.0001235667,0.00007558858,0.000008028767,0.00004250463,0.00001760456,0.000135656,0.9962682,0.00005006551,0.0001324087,0.002606009],"study_design_scores_gemma":[0.0001266012,0.004828139,0.002879168,0.00001328098,0.00004819472,0.0001947661,0.00005428883,0.001113321,0.9854581,0.0000304832,0.00524441,0.000009274704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844877,0.005029589,0.003243402,0.0002297389,0.0001649489,0.0001995787,0.00157832,0.0001491745,0.004917666],"genre_scores_gemma":[0.9749477,0.002467215,0.01061434,0.00032705,0.00003567368,0.0003510002,0.00383603,0.00004452402,0.007376502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002743716,"threshold_uncertainty_score":0.009178638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02865056409294507,"score_gpt":0.2972623005480282,"score_spread":0.2686117364550831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}