{"id":"W3022334807","doi":"10.1101/2020.05.01.073205","title":"Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Astrocyte; Glutamate receptor; Metabotropic glutamate receptor; Neurotransmission; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Astrogliosis; Synaptic plasticity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008197848,0.0004863717,0.0002930634,0.0003650716,0.0001852552,0.0002298354,0.0001918035,0.0002874369,0.001090621],"category_scores_gemma":[0.00007720874,0.0001613484,0.0002817594,0.0001712732,0.0003083293,0.0001642143,0.0002310993,0.0006323707,0.0002771079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003910398,"about_ca_system_score_gemma":0.0005118589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004882055,"about_ca_topic_score_gemma":0.007780261,"domain_scores_codex":[0.9999181,0.000006616902,0.000007144915,0.00001538232,0.00002227415,0.00003042289],"domain_scores_gemma":[0.9999239,0.00000276127,0.00002562707,0.000007318944,0.000008727458,0.00003164542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008598407,0.00007518656,0.0005370987,0.00005760181,0.00002612369,0.0002562256,0.00003801743,0.00009897687,0.9945861,0.0001724022,0.0001558121,0.003136604],"study_design_scores_gemma":[0.000191238,0.001114523,0.07493295,0.00004117743,0.0001443865,0.001737876,0.0004103692,0.002851644,0.9141496,0.0007033605,0.003697283,0.00002550708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99651,0.0009796816,0.001060059,0.0001400886,0.00004672917,0.00001013606,0.0002456013,0.00006593711,0.000941812],"genre_scores_gemma":[0.9949064,0.001174203,0.000847923,0.00007023196,0.00000998533,0.00003228743,0.000251152,0.00002828876,0.00267955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004882055,"threshold_uncertainty_score":0.009707272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04259923959421772,"score_gpt":0.2734871551331179,"score_spread":0.2308879155389002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}