{"id":"W3022336602","doi":"10.4212/cjhp.v73i2.2979","title":"Compounded Topical Amitriptyline for Neuropathic Pain: In Vitro Release from Compounding Bases and Potential Correlation with Clinical Efficacy","year":2020,"lang":"en","type":"article","venue":"The Canadian Journal of Hospital Pharmacy","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Dalhousie University","keywords":"Amitriptyline; Compounding; Permeation; Pharmacology; Drug; Poloxamer; Medicine; Chemistry; Chromatography; Membrane; Organic chemistry; Copolymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001406015,0.0001969172,0.0003579858,0.00008402095,0.0003181304,0.00005986922,0.0003206438,0.00009128045,0.00009774696],"category_scores_gemma":[0.0006516612,0.0001541299,0.0001192444,0.0001441713,0.000408222,0.0002145571,0.00002264003,0.001401733,0.000004325888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008958799,"about_ca_system_score_gemma":0.0004288097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004709639,"about_ca_topic_score_gemma":0.0003743297,"domain_scores_codex":[0.9974271,0.001138331,0.000683234,0.0002260936,0.0001672993,0.0003579437],"domain_scores_gemma":[0.997004,0.001694816,0.0003091266,0.00008772815,0.0001480109,0.0007562719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.05273977,0.002150503,0.374619,0.0002940975,0.002252641,0.0104979,0.008306169,0.09180428,0.02347227,0.0008240356,0.01373948,0.4192999],"study_design_scores_gemma":[0.06121689,0.006173357,0.02888647,0.0002514809,0.00207039,0.000267581,0.001298499,0.7153862,0.009207876,0.001329672,0.1723992,0.0015124],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680949,0.0008389729,0.01316983,0.01570825,0.001464988,0.0005566296,0.0001192463,0.00001205702,0.00003511693],"genre_scores_gemma":[0.9904463,0.0001275927,0.0006273878,0.00767559,0.001052611,0.000004580144,0.00003067563,0.00002650752,0.00000873509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6235819,"threshold_uncertainty_score":0.6285236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09945357117450951,"score_gpt":0.3863568697019715,"score_spread":0.286903298527462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}