{"id":"W3022345829","doi":"10.2147/ndt.s238985","title":"&lt;p&gt;Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia&lt;/p&gt;","year":2020,"lang":"en","type":"article","venue":"Neuropsychiatric Disease and Treatment","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Dementia; Cerebrospinal fluid; Apolipoprotein E; Internal medicine; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Endocrinology; Cognitive decline; Amyloid (mycology); Disease; Apolipoprotein B; Longitudinal study; Amyloid beta; Oncology; Pathology; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003169015,0.0003839063,0.0003191677,0.000390211,0.0003041272,0.000513265,0.0002251906,0.0004259684,0.000947866],"category_scores_gemma":[0.001083429,0.0002719277,0.0004774482,0.0003505922,0.0002215222,0.0002177609,0.0001980235,0.0005649011,0.0001826309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002253877,"about_ca_system_score_gemma":0.0002220906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008786797,"about_ca_topic_score_gemma":0.005639863,"domain_scores_codex":[0.9998831,0.00002026521,0.00001547337,0.00004496205,0.00001720217,0.00001907247],"domain_scores_gemma":[0.9993694,0.00008805401,0.0003229805,0.00005004607,0.00005783558,0.0001116801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006886951,0.00004799236,0.9957346,0.000008078717,0.0001176645,0.0002432491,0.00007224342,0.00005542408,0.001623397,0.00001079251,0.0001042108,0.001293491],"study_design_scores_gemma":[0.000007722259,0.00007605065,0.999141,0.000002133184,0.00005006652,0.0002338654,0.00003575207,0.000266406,0.0001157115,0.0000182618,0.00005093844,0.000002090628],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996314,0.00007289942,0.00008406443,0.00002012876,0.000004623178,0.000001719869,0.00009965824,0.000004907025,0.00008054307],"genre_scores_gemma":[0.9996177,0.00002201714,0.00005487794,0.00001522461,0.000004705117,0.000002080604,0.00009378491,0.000001713852,0.0001878997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008786797,"threshold_uncertainty_score":0.01747131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01748697308110424,"score_gpt":0.2623317434260203,"score_spread":0.2448447703449161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}