{"id":"W3022362948","doi":"10.1038/s42003-020-0942-0","title":"Methylation deficiency disrupts biological rhythms from bacteria to humans","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Japan Science and Technology Agency; National Institutes of Health; Kobayashi International Scholarship Foundation; UK Research and Innovation; Deutsche Forschungsgemeinschaft; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Core Research for Evolutional Science and Technology; Ministry of Education, Culture, Sports, Science and Technology; National Institute of General Medical Sciences; Kato Memorial Bioscience Foundation; Universidad Nacional de Quilmes; Senri Life Science Foundation; Agencia Nacional de Promoción Científica y Tecnológica; Wellcome Trust","keywords":"Biology; Methylation; Circadian rhythm; Circadian clock; Bacterial circadian rhythms; Cell cycle; Cyanobacteria; DNA methylation; Organism; Model organism; Cell biology; Genetics; Bacteria; Gene; Neuroscience; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001524415,0.0001404224,0.0001606822,0.00003551005,0.0001761619,0.00002174526,0.0006652971,0.0002111346,0.00006594686],"category_scores_gemma":[0.0003607364,0.0001288929,0.00007013607,0.0001503552,0.0001386626,0.000003504942,0.0005982117,0.0001102295,0.0001087022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001161313,"about_ca_system_score_gemma":0.00003228556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000404821,"about_ca_topic_score_gemma":0.00005260532,"domain_scores_codex":[0.9988065,0.0002868201,0.0002854767,0.0003860985,0.00004340391,0.0001916602],"domain_scores_gemma":[0.9985992,0.00006956624,0.00009014917,0.00101162,0.00009236552,0.0001371543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002645877,0.00004396842,0.01209354,0.000001394918,0.00001538467,1.349519e-7,0.0001903596,0.00002044551,0.977429,0.00233164,0.0001047659,0.007742944],"study_design_scores_gemma":[0.001007583,0.002076349,0.1578167,0.000013828,0.00005455337,0.000001583114,0.0002291276,0.001121571,0.3378244,0.01269989,0.4861714,0.0009830189],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9433345,0.002762802,0.04841508,0.003649566,0.000103052,0.0002414738,0.0001444113,0.0000331782,0.001315941],"genre_scores_gemma":[0.9819168,0.000759767,0.01415687,0.0009231679,0.0001807736,0.00004989158,0.001972078,0.0000144534,0.00002623303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6396046,"threshold_uncertainty_score":0.5256102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08423950523483185,"score_gpt":0.3417614831824951,"score_spread":0.2575219779476632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}