{"id":"W3022362948","doi":"10.1038/s42003-020-0942-0","title":"Methylation deficiency disrupts biological rhythms from bacteria to humans","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Japan Science and Technology Agency; National Institutes of Health; Kobayashi International Scholarship Foundation; UK Research and Innovation; Deutsche Forschungsgemeinschaft; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Core Research for Evolutional Science and Technology; Ministry of Education, Culture, Sports, Science and Technology; National Institute of General Medical Sciences; Kato Memorial Bioscience Foundation; Universidad Nacional de Quilmes; Senri Life Science Foundation; Agencia Nacional de Promoción Científica y Tecnológica; Wellcome Trust","keywords":"Biology; Methylation; Circadian rhythm; Circadian clock; Bacterial circadian rhythms; Cell cycle; Cyanobacteria; DNA methylation; Organism; Model organism; Cell biology; Genetics; Bacteria; Gene; Neuroscience; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229367,0.0002419729,0.0002254557,0.0002238394,0.0001606282,0.0002165909,0.0001591439,0.0003894108,0.001973126],"category_scores_gemma":[0.0003015691,0.0001377693,0.0001775681,0.0001280821,0.0002965621,0.0001193588,0.0003246014,0.0004307636,0.0003126286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000279494,"about_ca_system_score_gemma":0.0002550692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195842,"about_ca_topic_score_gemma":0.001087712,"domain_scores_codex":[0.9998455,0.00002599303,0.00001180073,0.00005167833,0.00003746024,0.00002751859],"domain_scores_gemma":[0.99988,0.00002443576,0.00003553307,0.00001962731,0.00000857004,0.00003184465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003070744,0.00002388374,0.001029848,0.00005620455,0.0000251605,0.0001850385,0.00003915459,0.00009717343,0.9914248,0.0004917011,0.0002032179,0.006116821],"study_design_scores_gemma":[0.00005193414,0.001021304,0.0313036,0.00004447724,0.0001085615,0.002693034,0.00015161,0.001335151,0.9363816,0.0007578526,0.02612259,0.00002827186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866398,0.005012034,0.003479342,0.0005795922,0.00009522269,0.00002773094,0.000663398,0.0002478938,0.003254925],"genre_scores_gemma":[0.9939536,0.002135096,0.001563809,0.0002490194,0.00001084659,0.00001994416,0.000288923,0.00004176223,0.001736918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001973126,"threshold_uncertainty_score":0.006600738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08423950523483185,"score_gpt":0.3417614831824951,"score_spread":0.2575219779476632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}