{"id":"W3022428923","doi":"10.1007/s12035-020-01907-4","title":"Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation","year":2020,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; European Regional Development Fund; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya; European Commission; CHDI Foundation; Ministerio de Ciencia, Innovación y Universidades; Instituto de Salud Carlos III; Comunidad de Madrid","keywords":"Induced pluripotent stem cell; Biology; Neuroscience; Embryonic stem cell; Cell biology; Transplantation; Striatum; Stem cell; Embryoid body; Ganglionic eminence; Neurotransmitter receptor; Progenitor cell; Neural stem cell; Dopamine; Receptor; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001536467,0.000263825,0.0002415453,0.00005604265,0.0001506289,0.00004424133,0.0003316235,0.0002189016,0.000004228026],"category_scores_gemma":[0.00002682945,0.0002140822,0.0001445947,0.0001639083,0.0001071956,0.000007154268,0.0001787985,0.00045048,0.000007794772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001599652,"about_ca_system_score_gemma":0.00004716602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002816572,"about_ca_topic_score_gemma":0.00004123156,"domain_scores_codex":[0.9979849,0.0005215741,0.0002915302,0.0006870571,0.0001452255,0.0003697368],"domain_scores_gemma":[0.999415,0.00002382893,0.0001009165,0.0002910909,0.0000444728,0.0001246563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002773506,0.00003628585,0.0003096374,0.0000462204,0.00003837145,0.0001668388,0.0002009977,0.0005290813,0.9980424,0.00001102379,0.0001716007,0.0001701744],"study_design_scores_gemma":[0.001288693,0.000376634,0.003441653,0.000008222892,0.00003653063,0.00002608152,0.0001978311,0.0002395119,0.9921575,0.00001546589,0.001971982,0.0002399142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949849,0.0004842954,0.0009387631,0.00288596,0.0001114109,0.0004470451,0.00003364071,0.00002465662,0.00008931979],"genre_scores_gemma":[0.996929,0.0001535321,0.00007954868,0.002194171,0.00005605199,0.00004296759,0.000325806,0.00004328936,0.0001756398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005884937,"threshold_uncertainty_score":0.8730018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078389310138884,"score_gpt":0.226350170343733,"score_spread":0.2155662772423442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}