{"id":"W3022428923","doi":"10.1007/s12035-020-01907-4","title":"Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation","year":2020,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; European Regional Development Fund; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya; European Commission; CHDI Foundation; Ministerio de Ciencia, Innovación y Universidades; Instituto de Salud Carlos III; Comunidad de Madrid","keywords":"Induced pluripotent stem cell; Biology; Neuroscience; Embryonic stem cell; Cell biology; Transplantation; Striatum; Stem cell; Embryoid body; Ganglionic eminence; Neurotransmitter receptor; Progenitor cell; Neural stem cell; Dopamine; Receptor; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574818,0.0004982829,0.0003085442,0.000318646,0.0001158719,0.0002960725,0.0002493806,0.0003312287,0.003060868],"category_scores_gemma":[0.0001414563,0.000269871,0.0002982185,0.0002173456,0.0001942654,0.0001799214,0.0002478151,0.000651136,0.001978521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341097,"about_ca_system_score_gemma":0.0002150515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002806917,"about_ca_topic_score_gemma":0.0005446009,"domain_scores_codex":[0.9997776,0.00001827142,0.00003450377,0.00004988531,0.00009352676,0.000026155],"domain_scores_gemma":[0.9998951,0.0000118199,0.0000265064,0.0000226506,0.00002476642,0.00001914432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002467544,0.00001484241,0.000184013,0.00006426997,0.000008451678,0.0001101291,0.00002249053,0.0001183533,0.9933229,0.0002362659,0.0002575304,0.005636131],"study_design_scores_gemma":[0.00001540347,0.0001588392,0.003496187,0.00002589079,0.00003043146,0.0005277691,0.00001626966,0.0008222645,0.9789926,0.0001604022,0.01574721,0.00000668465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7465816,0.008490542,0.1945644,0.0004126285,0.0004676479,0.001316409,0.01761928,0.003961421,0.02658605],"genre_scores_gemma":[0.8839494,0.007245457,0.05945485,0.0002340191,0.00005093924,0.0009429295,0.01430483,0.0005066785,0.03331103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003060868,"threshold_uncertainty_score":0.01023966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078389310138884,"score_gpt":0.226350170343733,"score_spread":0.2155662772423442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}