{"id":"W3022461752","doi":"10.1002/eji.201948435","title":"Pharmacological inhibition of RORC2 enhances human Th17‐Treg stability and function","year":2020,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Bristol-Myers Squibb","keywords":"Biology; Treg cell; Function (biology); Cell biology; Immunology; Immune system; T cell; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010329,0.0003602107,0.000400824,0.0001736597,0.0001089614,0.0002373518,0.0001764479,0.0001893271,0.002018716],"category_scores_gemma":[0.00009759248,0.0001097344,0.0002731674,0.0001270435,0.0001746043,0.00012303,0.000116784,0.0006606124,0.0005573159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001575432,"about_ca_system_score_gemma":0.0001589841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002757674,"about_ca_topic_score_gemma":0.0003735374,"domain_scores_codex":[0.9998094,0.00004937058,0.00001830335,0.0000247438,0.0000415936,0.00005649855],"domain_scores_gemma":[0.9999361,0.00001318724,0.00001652711,0.00001096592,0.000008387368,0.00001484147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002914293,0.00008316094,0.00006767097,0.0000408592,0.000006843389,0.00001694653,0.000008052109,0.0000661665,0.9983246,0.00003215982,0.00005021805,0.001011806],"study_design_scores_gemma":[0.0000742116,0.001165028,0.001359712,0.000003657376,0.00002272633,0.0001591643,0.00001211426,0.0005386217,0.9946849,0.00001172986,0.001964789,0.000003340753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994866,0.002119314,0.001404798,0.00007955511,0.00003764629,0.00003670186,0.0002711924,0.0000987749,0.001085983],"genre_scores_gemma":[0.9959077,0.0009020609,0.001253295,0.00004127896,0.00002758728,0.0000435509,0.0004419058,0.000015753,0.001366947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018716,"threshold_uncertainty_score":0.006753266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03621775840399927,"score_gpt":0.2462857024263021,"score_spread":0.2100679440223028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}