{"id":"W3022528142","doi":"10.1093/brain/awaa081","title":"Early clinical markers of aggressive multiple sclerosis","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Université de Montréal","funders":"Canadian Institutes of Health Research; Sanofi Genzyme; Novartis; Novartis Pharma; Multiple Sclerosis Society; European Committee for Treatment and Research in Multiple Sclerosis; Multiple Sclerosis Society of Canada; Univerzita Karlova v Praze; Teva Pharmaceutical Industries; Celgene; Biogen; Fondazione Italiana Sclerosi Multipla; Sanofi","keywords":"Multiple sclerosis; Medicine; Expanded Disability Status Scale; Cohort; Internal medicine; Pediatrics; Physical therapy; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001298782,0.0004891397,0.0006973555,0.001000521,0.0004136285,0.0009538843,0.00045347,0.0005350454,0.001825937],"category_scores_gemma":[0.00476227,0.0002822912,0.0003371583,0.001036721,0.0003839997,0.0006752589,0.0006685577,0.0009073443,0.0004030871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105522,"about_ca_system_score_gemma":0.000450512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001674917,"about_ca_topic_score_gemma":0.001736866,"domain_scores_codex":[0.999137,0.0003021192,0.0001132788,0.0001273217,0.0001772615,0.0001431397],"domain_scores_gemma":[0.9941426,0.001184708,0.003020653,0.0003533163,0.0005401312,0.0007586305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006783339,0.0001351212,0.9940904,0.00004166985,0.00003972383,0.0003336428,0.000131786,0.0001559063,0.001245493,0.00007366276,0.0001502905,0.002923994],"study_design_scores_gemma":[0.00002178832,0.0003421481,0.9978929,0.00001388592,0.0000304489,0.0006660001,0.00006478554,0.0001896896,0.0002377394,0.0001044216,0.0004280138,0.000008145196],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996605,0.000631267,0.0003658222,0.00004540876,0.000006009018,0.00008402969,0.0006291346,0.00002248804,0.001610753],"genre_scores_gemma":[0.997759,0.0002207199,0.0005250989,0.0000330707,0.00002553981,0.00006570563,0.0009121328,0.000005061748,0.0004536305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825937,"threshold_uncertainty_score":0.00686872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1855182351870754,"score_gpt":0.3715860596981745,"score_spread":0.1860678245110991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}