{"id":"W3022542397","doi":"10.1016/b0-12-227555-1/00517-7","title":"Li–Fraumeni Syndrome","year":2002,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Li–Fraumeni syndrome; Proband; Rhabdomyosarcoma; Medicine; Cancer; Sarcoma; Lung cancer; Internal medicine; Oncology; Pathology; Biology; Germline mutation; Mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001340922,0.0006805279,0.001077539,0.0003337148,0.00008365879,0.00003031239,0.0002251372,0.0009222141,0.004065891],"category_scores_gemma":[0.00002431369,0.0006734605,0.0006234999,0.0000232232,0.0001837792,0.00002380649,0.0001391218,0.001344915,0.003924585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004062096,"about_ca_system_score_gemma":0.0002150147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.052085e-7,"about_ca_topic_score_gemma":0.000004547001,"domain_scores_codex":[0.9974061,0.00001820033,0.0006168576,0.0007655516,0.0006990637,0.0004942132],"domain_scores_gemma":[0.9979174,0.00003021209,0.000272005,0.001258627,0.0001331488,0.0003886775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004100311,0.00002456272,0.000001833857,0.0002768946,0.0005612182,0.003910881,0.0001213913,6.326035e-7,0.0002161281,0.002069771,0.002671462,0.9901042],"study_design_scores_gemma":[0.001095272,0.0004045518,0.00001570246,0.001895123,0.0007888676,0.002966638,0.000001917907,0.000009564392,0.0001447913,0.001502002,0.9905725,0.0006031006],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.00009224119,0.006371225,0.000006836204,0.0001855674,0.0007519259,0.001183757,0.00005151958,0.0002617471,0.9910952],"genre_scores_gemma":[0.001811736,0.0004695536,0.0003155117,0.001050606,0.0004467629,0.00005721892,0.00007534079,0.0003338968,0.9954394],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.9895011,"threshold_uncertainty_score":0.9995717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01742772681036139,"score_gpt":0.2296904824384466,"score_spread":0.2122627556280852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}