{"id":"W3022545044","doi":"10.1158/0008-5472.can-19-1523","title":"Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Pancreatic Cancer Research Fund; Terry Fox Research Institute; Gerald O. Mann Charitable Foundation; National Cancer Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Sidney Kimmel Foundation for Cancer Research; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation; Government of Ontario; American Cancer Society","keywords":"Organoid; Pancreatic cancer; Cancer; Oncology; Internal medicine; Medicine; Outcome (game theory); Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496675,0.0001618113,0.0001648443,0.000467632,0.000138532,0.0003525927,0.00008863049,0.0002273445,0.0009578851],"category_scores_gemma":[0.0003078478,0.0001286976,0.0001921289,0.0002181638,0.0001570604,0.0001659541,0.0002410307,0.0003921896,0.0002185402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846458,"about_ca_system_score_gemma":0.0001092839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002637692,"about_ca_topic_score_gemma":0.000310641,"domain_scores_codex":[0.9998707,0.0000281763,0.00001666705,0.00002853525,0.00003318016,0.00002280376],"domain_scores_gemma":[0.9995372,0.00007945859,0.0001684175,0.00003689512,0.00004392667,0.0001340882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00351994,0.0001792902,0.3028068,0.00005393544,0.00007660232,0.001407768,0.0001864529,0.0004821313,0.6856604,0.00007619257,0.0001638593,0.00538681],"study_design_scores_gemma":[0.00003031267,0.001036267,0.8885811,0.00001193834,0.00006710752,0.003570381,0.0004706918,0.00187599,0.1029545,0.00009887797,0.001283076,0.00001966295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989896,0.0001841138,0.0003781962,0.00001327479,0.000001957022,0.000007006813,0.0001382644,0.00001264349,0.0002749859],"genre_scores_gemma":[0.9992297,0.00007561579,0.0001791338,0.000004844478,8.911111e-7,0.00001022172,0.0002649646,0.000002795044,0.0002319249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009578851,"threshold_uncertainty_score":0.003204405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2578945060778915,"score_gpt":0.5142480315451997,"score_spread":0.2563535254673082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}