{"id":"W3022545044","doi":"10.1158/0008-5472.can-19-1523","title":"Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Pancreatic Cancer Research Fund; Terry Fox Research Institute; Gerald O. Mann Charitable Foundation; National Cancer Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Sidney Kimmel Foundation for Cancer Research; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation; Government of Ontario; American Cancer Society","keywords":"Organoid; Pancreatic cancer; Cancer; Oncology; Internal medicine; Medicine; Outcome (game theory); Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001598169,0.0001211981,0.0009760705,0.0001800186,0.00005582497,0.000006614774,0.0001734731,0.0001867447,0.0009083985],"category_scores_gemma":[0.0008756056,0.00008895741,0.00005386659,0.0007263178,0.0008609197,0.00004234388,0.0001606418,0.0008003906,0.000004445229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002047153,"about_ca_system_score_gemma":0.0008610661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004872129,"about_ca_topic_score_gemma":0.001553226,"domain_scores_codex":[0.9973667,0.0004133124,0.0006507025,0.0003628518,0.0007895981,0.0004168329],"domain_scores_gemma":[0.9981298,0.0006779452,0.0001342735,0.0002541666,0.0005133956,0.0002904355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005876474,0.0002166386,0.9893872,0.0005613444,0.0002286863,0.00008655287,0.001278821,5.804997e-7,0.005375253,0.0000114274,0.0005505077,0.001715357],"study_design_scores_gemma":[0.004904976,0.001978776,0.986307,0.0009057865,0.000126241,0.000002784549,0.0004102424,0.0002439444,0.004932142,0.00003393627,0.00006429851,0.0000898648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947138,0.000651798,0.00001407884,0.003482144,0.0000158945,0.0006393216,0.00004578092,0.000009447454,0.0004276753],"genre_scores_gemma":[0.9978154,0.00108394,0.00002774251,0.0003799028,0.00008356538,0.00007730094,0.00001376558,0.00002576011,0.0004926642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004317328,"threshold_uncertainty_score":0.9946326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2578945060778915,"score_gpt":0.5142480315451997,"score_spread":0.2563535254673082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}