{"id":"W3022570927","doi":"10.1021/acsomega.0c00310","title":"Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple <i>N</i>-Methylations for Melanoma Imaging with Positron Emission Tomography","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; BC Cancer Foundation","keywords":"Positron emission tomography; Radioligand; Melanoma; Internalization; Melanocortin 1 receptor; Cancer research; Melanocyte-stimulating hormone; Chemistry; Positron Emission Tomography-Computed Tomography; Medicine; Receptor; Nuclear medicine; Internal medicine; Oncology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309255,0.0003024133,0.0001452441,0.00009126995,0.0001127911,0.0001290027,0.0003330958,0.0002514612,0.001415343],"category_scores_gemma":[0.0001318157,0.0001461884,0.0001481064,0.0001483426,0.0001809403,0.0001345073,0.0001332378,0.0003379917,0.000353443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003955077,"about_ca_system_score_gemma":0.000423565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001606182,"about_ca_topic_score_gemma":0.002491366,"domain_scores_codex":[0.999933,0.00001264967,0.000003305954,0.00001784137,0.0000148236,0.00001838466],"domain_scores_gemma":[0.9999655,0.000004972091,0.000009254868,0.00000494047,0.000005526334,0.000009791996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001455191,0.00001381692,0.00006609054,0.00003330894,0.000004503239,0.00005666864,0.00001449271,0.0002174652,0.9962593,0.0003109763,0.0001013694,0.002776537],"study_design_scores_gemma":[0.00002857274,0.0002786656,0.0003426325,0.000003156334,0.000008079921,0.0001286483,0.000007205199,0.0005321356,0.9960569,0.00004003402,0.002565952,0.000008010425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662987,0.002011194,0.0210904,0.0001951277,0.00005771639,0.0001914072,0.0005974162,0.0002508439,0.009307188],"genre_scores_gemma":[0.9836221,0.0008940402,0.00981765,0.00007169821,0.000005684659,0.00008130098,0.000686757,0.00005766159,0.004763051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606182,"threshold_uncertainty_score":0.004734814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00762918829177797,"score_gpt":0.2267565575629749,"score_spread":0.219127369271197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}