{"id":"W3022570927","doi":"10.1021/acsomega.0c00310","title":"Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple <i>N</i>-Methylations for Melanoma Imaging with Positron Emission Tomography","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; BC Cancer Foundation","keywords":"Positron emission tomography; Radioligand; Melanoma; Internalization; Melanocortin 1 receptor; Cancer research; Melanocyte-stimulating hormone; Chemistry; Positron Emission Tomography-Computed Tomography; Medicine; Receptor; Nuclear medicine; Internal medicine; Oncology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006224756,0.000205562,0.0002412768,0.00003853732,0.0001819044,0.00003762972,0.0001279352,0.00007125947,0.00000152809],"category_scores_gemma":[0.0001693689,0.0001516504,0.0001145751,0.0003399913,0.00005931767,0.00001204827,0.00005536687,0.0000915879,7.640435e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001490568,"about_ca_system_score_gemma":0.00003387655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002640451,"about_ca_topic_score_gemma":0.0000125109,"domain_scores_codex":[0.9989398,0.00003354075,0.0001829363,0.0004521184,0.0001351983,0.000256392],"domain_scores_gemma":[0.9993151,0.0001058061,0.0001270476,0.0001662001,0.0001507297,0.0001350777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000752434,0.00004143429,0.04053299,0.0000136596,0.0002139641,0.000001421599,0.0001239301,0.0002657337,0.9565808,0.000004163686,0.0002649887,0.00120451],"study_design_scores_gemma":[0.001927218,0.0006329774,0.004990081,0.00002876735,0.0001446872,0.000003038199,0.000167895,0.003259373,0.9867253,0.00002494039,0.001776967,0.0003187709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691663,0.0005319724,0.02891219,0.0007134046,0.00000514303,0.0003042539,0.00004278664,0.00003338743,0.000290595],"genre_scores_gemma":[0.9893636,0.00001883239,0.009789227,0.0003162429,0.0001230938,0.00006678364,0.0002532539,0.00003650634,0.00003252781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03554291,"threshold_uncertainty_score":0.6184123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00762918829177797,"score_gpt":0.2267565575629749,"score_spread":0.219127369271197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}