{"id":"W3022584141","doi":"10.3390/microorganisms8050710","title":"Elicitation of Cluster A and Co-Receptor Binding Site Antibodies Are Required to Eliminate HIV-1 Infected Cells","year":2020,"lang":"en","type":"article","venue":"Microorganisms","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Université de Montréal","keywords":"Antibody-dependent cell-mediated cytotoxicity; Antibody; Epitope; Polyclonal antibodies; Virology; Glycoprotein; Biology; Human immunodeficiency virus (HIV); Immunology; Chemistry; Molecular biology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583784,0.0002363176,0.00019294,0.000116729,0.0001087158,0.0001848507,0.0001455022,0.0002979749,0.0008101958],"category_scores_gemma":[0.0001812713,0.00009018875,0.0001417447,0.00006932931,0.000142304,0.0001161311,0.0001576663,0.0003908702,0.0001670376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331534,"about_ca_system_score_gemma":0.000176574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005136097,"about_ca_topic_score_gemma":0.0008288832,"domain_scores_codex":[0.9997824,0.00004524674,0.00001203074,0.00002979865,0.00005992664,0.00007057677],"domain_scores_gemma":[0.9998969,0.00002585312,0.00002180521,0.00001666049,0.00001424778,0.00002448591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006359723,0.00003379544,0.0001350908,0.00001542411,0.00000186617,0.00001306475,0.00000619221,0.00004099846,0.9989625,0.00006054565,0.00001378638,0.0006530486],"study_design_scores_gemma":[0.00001646999,0.0009327074,0.005371629,0.000005221272,0.0000112264,0.000193097,0.00001610223,0.0005619209,0.991102,0.00003717674,0.001750114,0.000002458366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970976,0.0004059617,0.001311628,0.00002746978,0.00001246795,0.00003008994,0.00004224852,0.00002393369,0.001048594],"genre_scores_gemma":[0.9968072,0.0001509966,0.001503086,0.00003282982,0.0000076534,0.00002385807,0.0001131137,0.000006523416,0.001354748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008101958,"threshold_uncertainty_score":0.002710402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01569930845264168,"score_gpt":0.2558239736177269,"score_spread":0.2401246651650852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}