{"id":"W3022594203","doi":"10.1016/j.ccell.2020.04.004","title":"Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response","year":2020,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":false,"ca_institutions":"Spinal Cord Injury BC","funders":"Janssen Pharmaceuticals; National Institute of General Medical Sciences; National Institutes of Health; Leukemia and Lymphoma Society; Michael Smith Health Research BC; National Institute of Allergy and Infectious Diseases; Terry Fox Research Institute; Bristol-Myers Squibb; Bayer Corporation; National Cancer Institute; AbbVie; Pharmaceutical Research and Manufacturers of America Foundation; Damon Runyon Cancer Research Foundation; American Society of Hematology; Uehara Memorial Foundation; Chemotherapy Foundation","keywords":"Reprogramming; Niche; Immune system; Biology; Mutant; Lymphoma; EZH2; Cancer research; Immunology; Cell biology; Cell; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002911176,0.0001325503,0.0001103929,0.000006244996,0.0001035614,0.00004026837,0.0002300075,0.0001118632,0.00003071328],"category_scores_gemma":[0.00008541498,0.00009825032,0.00007864426,0.00009242194,0.00005650797,0.000002957486,0.0001083507,0.00005613502,0.000005379888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002473723,"about_ca_system_score_gemma":0.000124112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001590367,"about_ca_topic_score_gemma":0.00001479562,"domain_scores_codex":[0.9989741,0.0001330425,0.0002057656,0.0003573326,0.0001185262,0.0002111865],"domain_scores_gemma":[0.9993797,0.00002560575,0.0001134615,0.0003423757,0.00005255767,0.00008629137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003497159,0.00002652005,0.0002382254,0.00001232479,0.00002116761,0.000002015253,0.0004400981,0.00004775705,0.9833717,0.000002580253,0.0004138654,0.01507402],"study_design_scores_gemma":[0.0003197528,0.0002138887,0.001005907,0.000006485463,0.00001688506,5.380387e-7,0.0001490296,0.0000730805,0.7988275,0.000008356878,0.1992597,0.0001188087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9433647,0.05431799,0.0005025875,0.001095506,0.0001240182,0.000207391,0.00002447834,0.0000135206,0.0003497536],"genre_scores_gemma":[0.9960853,0.002504609,0.0001157323,0.0004795466,0.0002033738,0.00006749452,0.00003561752,0.00002496421,0.0004832932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1988459,"threshold_uncertainty_score":0.4006532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452332610476352,"score_gpt":0.2615278053602283,"score_spread":0.2470044792554648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}