{"id":"W3022616650","doi":"10.1681/asn.2019111168","title":"Renal, Cardiovascular, and Safety Outcomes of Canagliflozin by Baseline Kidney Function: A Secondary Analysis of the CREDENCE Randomized Trial","year":2020,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of British Columbia; Mount Sinai Hospital","funders":"Janssen Research and Development; Relypsa; Bristol-Myers Squibb; Akebia Therapeutics; Daiichi Sankyo Europe; Gilead Sciences; Servier; Eisai; Astellas Pharma; Novo Nordisk; NxStage; AstraZeneca; Amarin Corporation; Ironwood Pharmaceuticals, Incorporated; Regeneron Pharmaceuticals; Alnylam Pharmaceuticals; Kidney Foundation of Canada; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; GlaxoSmithKline; Amgen; Innovent Biologics; Pfizer; Celgene; Eli Lilly and Company; Janssen Pharmaceuticals; University of Washington","keywords":"Canagliflozin; Medicine; Renal function; Randomized controlled trial; Credence; Internal medicine; Urology; Intensive care medicine; Endocrinology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001235595,0.0001353954,0.002141338,0.00005533053,0.00004564239,0.000003121265,0.0002144759,0.0000411775,0.00007284219],"category_scores_gemma":[0.0003194337,0.00006933211,0.00307496,0.0006863801,0.0009441691,0.0000375905,0.0001204685,0.0002035269,1.033322e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003493941,"about_ca_system_score_gemma":0.0001854818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003890391,"about_ca_topic_score_gemma":0.000009182408,"domain_scores_codex":[0.9980128,0.0005042143,0.0007850823,0.0001344223,0.0004329815,0.0001305183],"domain_scores_gemma":[0.997519,0.0003966734,0.001472202,0.0003245406,0.0001749153,0.0001127355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4437017,0.0004936091,0.01714801,0.0002053321,0.2061369,0.000004806567,0.001584647,0.0005521064,0.01066845,0.00004466117,0.3092043,0.01025543],"study_design_scores_gemma":[0.7069046,0.003592047,0.08718613,0.00008768605,0.1010947,0.0000144904,0.001836468,0.001969472,0.0007764151,0.00009130339,0.09624587,0.0002008535],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9403465,0.002305813,0.002051214,0.05424812,0.0001437617,0.0006923439,0.00006252455,0.000005051938,0.0001446126],"genre_scores_gemma":[0.9714695,0.001595073,0.001061869,0.02556232,0.000123902,0.000006100638,0.000005859783,0.00001094157,0.0001644643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2632029,"threshold_uncertainty_score":0.347883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196732480465095,"score_gpt":0.2450311863132118,"score_spread":0.2330638615085608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}