{"id":"W3022616650","doi":"10.1681/asn.2019111168","title":"Renal, Cardiovascular, and Safety Outcomes of Canagliflozin by Baseline Kidney Function: A Secondary Analysis of the CREDENCE Randomized Trial","year":2020,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of British Columbia; Mount Sinai Hospital","funders":"Janssen Research and Development; Relypsa; Bristol-Myers Squibb; Akebia Therapeutics; Daiichi Sankyo Europe; Gilead Sciences; Servier; Eisai; Astellas Pharma; Novo Nordisk; NxStage; AstraZeneca; Amarin Corporation; Ironwood Pharmaceuticals, Incorporated; Regeneron Pharmaceuticals; Alnylam Pharmaceuticals; Kidney Foundation of Canada; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; GlaxoSmithKline; Amgen; Innovent Biologics; Pfizer; Celgene; Eli Lilly and Company; Janssen Pharmaceuticals; University of Washington","keywords":"Canagliflozin; Medicine; Renal function; Randomized controlled trial; Credence; Internal medicine; Urology; Intensive care medicine; Endocrinology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0124471,0.001715711,0.003854459,0.001130781,0.0005147095,0.001693301,0.0008692101,0.001599442,0.008524523],"category_scores_gemma":[0.02177241,0.0005709981,0.007853314,0.001213053,0.001034157,0.001362901,0.0008885906,0.002898259,0.0006075656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008061473,"about_ca_system_score_gemma":0.001156135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217213,"about_ca_topic_score_gemma":0.001260983,"domain_scores_codex":[0.990704,0.006218846,0.0006017487,0.001051995,0.0008388648,0.0005845908],"domain_scores_gemma":[0.9852502,0.007053503,0.003016408,0.002427558,0.001311515,0.0009409353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9507605,0.002400646,0.01277111,0.001629435,0.01448542,0.00007710433,0.00006498083,0.001002245,0.0006752386,0.0008117504,0.004553136,0.01076833],"study_design_scores_gemma":[0.8484402,0.03275275,0.07046078,0.000315677,0.03072242,0.0001677121,0.00009143899,0.006184176,0.001617089,0.003091009,0.006015268,0.0001415736],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609338,0.007810041,0.003527598,0.001728018,0.001449818,0.005555316,0.01172875,0.0002677837,0.00699908],"genre_scores_gemma":[0.982295,0.0007704017,0.001932859,0.0009418827,0.001003556,0.004493173,0.005675985,0.000045603,0.002841539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0124471,"threshold_uncertainty_score":0.06582737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196732480465095,"score_gpt":0.2450311863132118,"score_spread":0.2330638615085608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}