{"id":"W3022668259","doi":"10.1007/s10456-020-09723-z","title":"Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice","year":2020,"lang":"en","type":"article","venue":"Angiogenesis","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; American Heart Association; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; March of Dimes Foundation","keywords":"Decidualization; Notch signaling pathway; Angiogenesis; Regulator; Biology; ADAM10; Cell biology; Endothelial stem cell; Endocrinology; Internal medicine; Endometrium; Signal transduction; Andrology; Disintegrin; Cancer research; Metalloproteinase; Matrix metalloproteinase; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125644,0.000109356,0.0003149594,0.00007211854,0.00003230065,0.000002631312,0.00008111366,0.0001308902,0.00006062895],"category_scores_gemma":[0.0001857888,0.00009335861,0.00008302182,0.0002211098,0.00009099113,0.00006033378,0.00003623392,0.00003015535,0.000006145638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001148232,"about_ca_system_score_gemma":0.00004424947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004459487,"about_ca_topic_score_gemma":0.0000399078,"domain_scores_codex":[0.9988738,0.0002727126,0.0003888335,0.0002949033,0.00003854985,0.0001312404],"domain_scores_gemma":[0.9994385,0.00006923703,0.0001877028,0.0001714848,0.0001151285,0.00001792746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002622024,0.00004887212,0.09815387,0.0001188033,0.00007533333,9.150274e-7,0.002409259,0.00001425509,0.8981889,0.00003306994,0.00004640777,0.0006480381],"study_design_scores_gemma":[0.0005076917,0.0001081146,0.2414988,0.00006648842,0.00003983207,0.000004532172,0.0002125223,0.000002055914,0.75734,0.00002661266,0.000121376,0.00007198723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914284,0.00783048,0.0001428129,0.000127832,0.0001018139,0.0002642416,0.00006370459,0.00001794136,0.00002275859],"genre_scores_gemma":[0.9996912,0.00004938622,0.0001054985,0.00002570448,0.00002268951,0.00001283386,0.00003736144,0.00001071882,0.00004462945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.143345,"threshold_uncertainty_score":0.3807054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0262201959672814,"score_gpt":0.2439860700846355,"score_spread":0.2177658741173541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}