{"id":"W3022787149","doi":"10.1016/j.bonr.2020.100264","title":"Altered topological blueprint of trabecular bone associates with skeletal pathology in humans","year":2020,"lang":"en","type":"article","venue":"Bone Reports","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Object Research Systems (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Topology (electrical circuits); Trabecular bone; Osteocyte; Biology; Chemistry; Materials science; Biomedical engineering; Medicine; Pathology; Osteoporosis; Mathematics; Osteoblast","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631582,0.0002620603,0.0002249489,0.001459536,0.0002117959,0.0004453812,0.0001804033,0.0003694311,0.002007131],"category_scores_gemma":[0.0008064827,0.0002894325,0.0001669351,0.0008219515,0.0005920657,0.0002738493,0.0003144446,0.000184541,0.0002576239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009644144,"about_ca_system_score_gemma":0.00009086563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005843786,"about_ca_topic_score_gemma":0.0007497611,"domain_scores_codex":[0.9998531,0.00002859484,0.00001252924,0.00005186882,0.00003888891,0.00001500561],"domain_scores_gemma":[0.9996081,0.00003909052,0.0002426689,0.00004490259,0.00002842285,0.00003688894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001453706,0.0001355283,0.7366979,0.0001705867,0.0003058065,0.002511849,0.0008092902,0.001506941,0.2189689,0.001324855,0.0005967284,0.03551789],"study_design_scores_gemma":[0.000007637463,0.0001987167,0.9874272,0.00001033654,0.00005654381,0.005473118,0.000198108,0.0008742935,0.00435708,0.0008690672,0.000509578,0.00001838025],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973449,0.0002963753,0.001685091,0.00002414357,0.000004109786,0.00000574316,0.000175326,0.00002665786,0.0004376523],"genre_scores_gemma":[0.9987771,0.0001536421,0.0006753723,0.000008797786,0.000006100694,0.00000418841,0.0001298616,0.000007950949,0.0002370278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002007131,"threshold_uncertainty_score":0.006714523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121920381997378,"score_gpt":0.2335229962480252,"score_spread":0.2223037924280515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}