{"id":"W3022795538","doi":"10.1038/s41416-020-0874-y","title":"Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion","year":2020,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"National Institute for Health and Care Research; Cancer Research UK; World Health Organization","keywords":"Downregulation and upregulation; Indoleamine 2,3-dioxygenase; Cancer research; Nicotinamide phosphoribosyltransferase; Biology; Kynurenine; Immune system; Immunology; NAD+ kinase; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004221377,0.0002450387,0.0005660499,0.0004202765,0.0001848707,0.0006526523,0.0002972576,0.0003529739,0.000957569],"category_scores_gemma":[0.0003919241,0.0000869633,0.000233103,0.000390408,0.0003584652,0.0003842758,0.0002817333,0.0004800201,0.0002788802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004908387,"about_ca_system_score_gemma":0.000367978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005739292,"about_ca_topic_score_gemma":0.0006588952,"domain_scores_codex":[0.9996893,0.0000473138,0.00003071866,0.00007604335,0.0001108809,0.00004571728],"domain_scores_gemma":[0.9995363,0.00005327606,0.0002414794,0.00003352832,0.00007529907,0.00006005798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005236694,0.00005025809,0.03831002,0.0003057177,0.00009972554,0.0007575791,0.00009725944,0.0003165278,0.9403509,0.0004044681,0.0001543663,0.01862941],"study_design_scores_gemma":[0.00003661633,0.0009981816,0.500089,0.0001098001,0.0002047334,0.009300935,0.0004441659,0.002261339,0.4755811,0.001306672,0.009627846,0.00003945445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749049,0.01820489,0.004757831,0.0003647771,0.00002727852,0.00003241413,0.0003475465,0.00008809016,0.001272341],"genre_scores_gemma":[0.9953774,0.002499329,0.001440622,0.00005375457,0.00001600787,0.00001204227,0.0001981535,0.000006127837,0.0003965888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000957569,"threshold_uncertainty_score":0.003561318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02757297852138995,"score_gpt":0.2764715563612481,"score_spread":0.2488985778398581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}