{"id":"W3022803855","doi":"10.1101/2020.04.29.20075747","title":"Development and validation of direct RT-LAMP for SARS-CoV-2","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Biosensors and Analytical Detection","field":"Engineering","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Provincial Laboratory of Public Health; University of Calgary","funders":"Genome Canada; M.J. Murdock Charitable Trust","keywords":"Reverse transcriptase; Detection limit; Virology; Recombinant DNA; Molecular biology; Gene; Real-time polymerase chain reaction; RNA extraction; Biology; RNA; Reverse transcription polymerase chain reaction; Chemistry; Chromatography; Messenger RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003064718,0.0009035152,0.0006741015,0.000504674,0.0003398999,0.0009151808,0.0007324531,0.0009370391,0.000986292],"category_scores_gemma":[0.00213893,0.0004668683,0.0006901398,0.0002533585,0.0004926933,0.000359168,0.0005897589,0.0007454387,0.001501565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005919109,"about_ca_system_score_gemma":0.0007467655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009774347,"about_ca_topic_score_gemma":0.000840911,"domain_scores_codex":[0.9962196,0.000989566,0.0002487556,0.0007352151,0.001598694,0.0002081446],"domain_scores_gemma":[0.9990391,0.0002165009,0.00007511218,0.000155246,0.0004720465,0.00004203093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004247642,0.00003737829,0.0004037435,0.00005909568,0.000008048352,0.00002811571,0.0000400241,0.0002751537,0.9935601,0.00007897115,0.0001139817,0.005352881],"study_design_scores_gemma":[0.000006538031,0.0001983319,0.0008285373,0.00001005697,0.00001231468,0.0001859478,0.00001186463,0.001859951,0.9944379,0.00003297657,0.002406897,0.000008649507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6660417,0.002851096,0.3204817,0.0004063866,0.0003025088,0.001315178,0.001760817,0.001847045,0.004993714],"genre_scores_gemma":[0.5624563,0.001628709,0.4210485,0.0002899027,0.00006844173,0.0009688435,0.004254667,0.0003382518,0.008946513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003064718,"threshold_uncertainty_score":0.01620799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04839539045308545,"score_gpt":0.2633444314399314,"score_spread":0.2149490409868459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}