{"id":"W3022803855","doi":"10.1101/2020.04.29.20075747","title":"Development and validation of direct RT-LAMP for SARS-CoV-2","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Biosensors and Analytical Detection","field":"Engineering","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Provincial Laboratory of Public Health; University of Calgary","funders":"Genome Canada; M.J. Murdock Charitable Trust","keywords":"Reverse transcriptase; Detection limit; Virology; Recombinant DNA; Molecular biology; Gene; Real-time polymerase chain reaction; RNA extraction; Biology; RNA; Reverse transcription polymerase chain reaction; Chemistry; Chromatography; Messenger RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001001518,0.0001206464,0.0002137867,0.00004595107,0.00001729118,0.00001730549,0.00005427256,0.0001242159,0.000002121824],"category_scores_gemma":[0.00004174882,0.0001164753,0.00005258032,0.00004986771,0.00001317263,0.00001574078,0.00005175015,0.0001209374,0.000003652013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002215617,"about_ca_system_score_gemma":0.00001112409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003114914,"about_ca_topic_score_gemma":0.000003899086,"domain_scores_codex":[0.9994374,0.000008091599,0.0002126198,0.0001717544,0.00008015893,0.00008998816],"domain_scores_gemma":[0.9997876,0.00002687236,0.00003760773,0.00009449946,0.00002818014,0.00002526434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003252811,0.00003241246,0.001061211,0.003941543,0.0003429379,0.000003232011,0.0008070304,0.002070501,0.9575338,0.0003443129,0.0008054763,0.03302503],"study_design_scores_gemma":[0.00009161007,0.00001107743,0.001353856,0.000072214,0.00003035038,3.716901e-7,0.000005487236,0.02463566,0.9614171,0.0003979771,0.0118449,0.0001394018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984522,0.0001093398,0.01392483,0.00008319493,0.0002840718,0.000187801,0.00001592541,0.0001160013,0.0007568188],"genre_scores_gemma":[0.9939113,0.00004775256,0.005865016,0.00001361998,0.00007325468,0.00002477594,0.00002037281,0.00002206892,0.00002179441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03288563,"threshold_uncertainty_score":0.4749723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04839539045308545,"score_gpt":0.2633444314399314,"score_spread":0.2149490409868459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}