{"id":"W3022841462","doi":"10.1183/13993003.01261-2020","title":"COVID-19 and nicotine as a mediator of ACE-2","year":2020,"lang":"en","type":"letter","venue":"European Respiratory Journal","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Downregulation and upregulation; Medicine; Nicotine; Transcriptome; Angiotensin-converting enzyme 2; Gene silencing; Receptor; Mediator; COPD; Pharmacology; Coronavirus disease 2019 (COVID-19); Gene; Internal medicine; Gene expression; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008696886,0.0004474499,0.0005274376,0.0001296375,0.0001700286,0.00006215765,0.0007183134,0.0003281641,0.0002905558],"category_scores_gemma":[0.002301342,0.0004049487,0.0002671024,0.0001149767,0.0002747482,0.000005195308,0.0005929662,0.002001017,0.0001026475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000475395,"about_ca_system_score_gemma":0.001033897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000190774,"about_ca_topic_score_gemma":0.000001309579,"domain_scores_codex":[0.9963855,0.001284598,0.0008143516,0.0006226,0.0004888424,0.0004041663],"domain_scores_gemma":[0.9977193,0.00005945341,0.000873516,0.0005142734,0.0001611437,0.0006723429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006261675,0.00002607934,0.0008558439,0.0001332123,0.0002060708,0.0002473067,0.0000891523,0.00000184174,0.03160769,0.000001128728,0.9662794,0.000489613],"study_design_scores_gemma":[0.001286335,0.0008624326,0.00003421834,0.0000397056,0.00008835446,0.0004974482,0.00004234339,4.18967e-7,0.01011122,0.000007229702,0.9866589,0.0003713954],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1774119,0.03514706,0.0007325127,0.768644,0.003017419,0.001284384,0.0003920204,0.0001268961,0.01324377],"genre_scores_gemma":[0.007032704,0.001384359,0.0004450883,0.9707951,0.01854751,0.000004342322,0.0001066145,0.000251755,0.001432546],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.202151,"threshold_uncertainty_score":0.9998403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02763009254356096,"score_gpt":0.2897389010330781,"score_spread":0.2621088084895172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}