{"id":"W3022841462","doi":"10.1183/13993003.01261-2020","title":"COVID-19 and nicotine as a mediator of ACE-2","year":2020,"lang":"en","type":"letter","venue":"European Respiratory Journal","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Downregulation and upregulation; Medicine; Nicotine; Transcriptome; Angiotensin-converting enzyme 2; Gene silencing; Receptor; Mediator; COPD; Pharmacology; Coronavirus disease 2019 (COVID-19); Gene; Internal medicine; Gene expression; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007573233,0.0003594829,0.0006011379,0.0003171597,0.000814627,0.000842389,0.0004765256,0.00744253,0.002560079],"category_scores_gemma":[0.00476506,0.0001838796,0.0003433578,0.0002126022,0.0006801471,0.0008447776,0.0003411781,0.005993289,0.002818102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009056226,"about_ca_system_score_gemma":0.0003887164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006269696,"about_ca_topic_score_gemma":0.0007432809,"domain_scores_codex":[0.9993764,0.0001864017,0.00007262258,0.00009964602,0.0001767629,0.00008814099],"domain_scores_gemma":[0.9981998,0.001095403,0.0001475305,0.00009257501,0.0002543955,0.0002102202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009168503,0.0002414516,0.01612832,0.0003955206,0.00007122316,0.1883469,0.000436519,0.0001421955,0.007220146,0.008735307,0.7114971,0.06586842],"study_design_scores_gemma":[0.0003525098,0.0005592132,0.0194012,0.0005401609,0.00009841889,0.2450957,0.0006712754,0.001670214,0.004455811,0.01481433,0.7122663,0.00007480833],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02617859,0.01822173,0.0009297742,0.9036846,0.03276974,0.00005166831,0.0001701074,0.0001426525,0.01785117],"genre_scores_gemma":[0.2481243,0.01201672,0.001181996,0.5770341,0.1316016,0.0001074308,0.0001780116,0.00006970595,0.02968613],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.00744253,"threshold_uncertainty_score":0.008564293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02763009254356096,"score_gpt":0.2897389010330781,"score_spread":0.2621088084895172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}