{"id":"W3022862037","doi":"10.1101/2020.04.29.067835","title":"Proteomic and functional mapping of cardiac Na <sub>V</sub> 1.5 channel phosphorylation reveals multisite regulation of surface expression and gating","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bioinformatics Solutions (Canada)","funders":"","keywords":"Phosphorylation; Gating; HEK 293 cells; Serine; Immunoprecipitation; Protein subunit; Chemistry; Biophysics; Molecular biology; Cell biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008472496,0.0001992168,0.0001540625,0.0001887336,0.0001416443,0.000245663,0.0001404525,0.0001680468,0.000574855],"category_scores_gemma":[0.0001044087,0.0001231008,0.0002237114,0.0001080978,0.0001150446,0.0001902649,0.0001460722,0.000204901,0.0002485086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001867452,"about_ca_system_score_gemma":0.0001229323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005204875,"about_ca_topic_score_gemma":0.0008850959,"domain_scores_codex":[0.9999405,0.000005306732,0.000004846325,0.00001902608,0.00001642088,0.00001376385],"domain_scores_gemma":[0.9999447,0.000007197918,0.00001813803,0.000005394988,0.000008694659,0.00001593564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004152058,0.000003635343,0.0004624183,0.00001417301,0.000003627537,0.00001830733,0.000005182636,0.00001975722,0.9990506,0.00002579611,0.000011338,0.0003437242],"study_design_scores_gemma":[0.00001974235,0.0001830897,0.1928622,0.00001345195,0.0000494306,0.0009741979,0.0001236222,0.004248783,0.7994394,0.0002079023,0.001865767,0.00001232694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995317,0.0006305305,0.003016298,0.00004569966,0.00001068004,0.00001125256,0.0004101948,0.00002179451,0.0005364997],"genre_scores_gemma":[0.9930215,0.000609581,0.003889232,0.00006040362,0.00001131043,0.00001911197,0.001174244,0.00002046222,0.001194086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000574855,"threshold_uncertainty_score":0.001923084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0143757377974595,"score_gpt":0.2089938410256544,"score_spread":0.1946181032281949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}