{"id":"W3022881179","doi":"10.1210/jendso/bvaa046.147","title":"OR29-01 Long-Term Safety in Adults with X-Linked Hypophosphatemia (XLH) Treated with Burosumab, a Fully Human Monoclonal Antibody Against FGF23: Final Results of a Phase 3 Trial","year":2020,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Hypophosphatemia; Placebo; Internal medicine; Hyperphosphatemia; Gastroenterology; Pediatrics; Surgery; Kidney disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261685,0.0003744693,0.0009545963,0.00006096816,0.0001391781,0.00002304057,0.0002911489,0.00008004151,0.00001533265],"category_scores_gemma":[0.00009982873,0.0002062747,0.0005803785,0.0006089255,0.0001999023,0.0001650221,0.00006814066,0.0006713454,0.000001967425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001732573,"about_ca_system_score_gemma":0.0004232113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000699845,"about_ca_topic_score_gemma":0.00003062061,"domain_scores_codex":[0.9972779,0.0001134841,0.001137666,0.0003360931,0.0007270658,0.0004077613],"domain_scores_gemma":[0.9979479,0.00007655266,0.001104287,0.0003300299,0.0002719003,0.0002692738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7780055,0.006475277,0.1773937,0.0002156799,0.00242458,0.003541976,0.004799611,0.0004692213,0.02005175,0.00001238681,0.00543219,0.001178073],"study_design_scores_gemma":[0.8124529,0.02129049,0.15515,0.001034421,0.0009290898,0.0006639892,0.0008559878,0.0005085156,0.006359614,0.00001033992,0.0003666634,0.0003779641],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956104,0.001085996,0.00003996538,0.001862707,0.00006675359,0.0009616725,0.00009126088,0.00001887918,0.000262367],"genre_scores_gemma":[0.997927,0.0005703991,0.000507137,0.0003512322,0.0002679965,0.000009169037,0.00009354762,0.00004047429,0.0002330323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03444739,"threshold_uncertainty_score":0.8411637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708818323390165,"score_gpt":0.3212145914282164,"score_spread":0.2941264081943147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}