{"id":"W3022881179","doi":"10.1210/jendso/bvaa046.147","title":"OR29-01 Long-Term Safety in Adults with X-Linked Hypophosphatemia (XLH) Treated with Burosumab, a Fully Human Monoclonal Antibody Against FGF23: Final Results of a Phase 3 Trial","year":2020,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Hypophosphatemia; Placebo; Internal medicine; Hyperphosphatemia; Gastroenterology; Pediatrics; Surgery; Kidney disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001508558,0.0006953852,0.00129065,0.000149893,0.0003372478,0.0007355483,0.0004597639,0.001322105,0.003732329],"category_scores_gemma":[0.0009291698,0.0002026742,0.001309308,0.0001626866,0.0004789214,0.0005263549,0.0002191506,0.002209207,0.0008625955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003379002,"about_ca_system_score_gemma":0.0006555355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005562633,"about_ca_topic_score_gemma":0.001384418,"domain_scores_codex":[0.9996257,0.0002146839,0.00002338324,0.00004272009,0.00003907943,0.00005450867],"domain_scores_gemma":[0.9994227,0.0001547568,0.0001149149,0.00003926356,0.00006138794,0.0002070046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7978233,0.01571364,0.005628501,0.002283304,0.002316948,0.000472831,0.0002687174,0.001011888,0.02846145,0.0004696843,0.01055561,0.1349941],"study_design_scores_gemma":[0.721787,0.2510849,0.01661969,0.0001883491,0.0007766954,0.0005302877,0.00007715042,0.0009919209,0.001846874,0.0004197987,0.00564052,0.00003682928],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736453,0.01452588,0.0009306713,0.001485345,0.0002885789,0.001787031,0.002436536,0.0002216588,0.004678968],"genre_scores_gemma":[0.9859789,0.004498012,0.001410761,0.002182755,0.0002471664,0.001219695,0.002169434,0.00002891547,0.002264412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003732329,"threshold_uncertainty_score":0.01248586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708818323390165,"score_gpt":0.3212145914282164,"score_spread":0.2941264081943147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}