{"id":"W3022903993","doi":"10.3389/fmicb.2020.00805","title":"Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus","year":2020,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Microbiology; Staphylococcus aureus; Virulence; Aminoglycoside; ATP synthase; Biology; Staphylococcus; Bacteria; Enzyme; Antibiotics; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264129,0.0003493403,0.0004037055,0.0002411125,0.00007458709,0.000206479,0.0002131195,0.0002836529,0.0008085581],"category_scores_gemma":[0.0001822929,0.0001258062,0.0002589093,0.0001349266,0.0001409317,0.000139972,0.0002076274,0.0003467613,0.0001670324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001284958,"about_ca_system_score_gemma":0.0002180538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005620134,"about_ca_topic_score_gemma":0.0009550415,"domain_scores_codex":[0.9997754,0.00005386176,0.00002924542,0.00003119007,0.00006560588,0.00004485972],"domain_scores_gemma":[0.999885,0.00002126645,0.00002705224,0.0000112812,0.00001743196,0.00003803802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004037038,0.000103819,0.0002014608,0.00006062209,0.00001406068,0.00003571733,0.00001350488,0.00008993366,0.9965275,0.00002708185,0.00004948246,0.00247322],"study_design_scores_gemma":[0.00007733481,0.003499466,0.00654374,0.00001132805,0.00003679029,0.0002578284,0.00003463773,0.000951651,0.987207,0.00001955174,0.001352082,0.000008485338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964954,0.001849068,0.0005036427,0.00006016485,0.00003286629,0.0000247593,0.0001350288,0.00002628069,0.0008727772],"genre_scores_gemma":[0.9972073,0.0007631432,0.000855976,0.00002622418,0.00001320996,0.00002550267,0.0002043765,0.000005728322,0.0008985132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008085581,"threshold_uncertainty_score":0.002704918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006590087631869457,"score_gpt":0.1849284254990718,"score_spread":0.1783383378672024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}